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SciCrunch Registry is a curated repository of scientific resources, with a focus on biomedical resources, including tools, databases, and core facilities - visit SciCrunch to register your resource.
http://www.hcbi.fas.harvard.edu
Microscopy facility. Contains microscopes including confocal, super-resolution, multi-photon, light sheet, live cell imaging, high-content screening, slide scanning, laser dissection and macroscopy stations. Features wet lab space, eukaryotic and prokaryotic incubation, and access to nearby animal care facilities for wide range of species.Services include Cell Imaging,Confocal Microscopy,Consultations,Data Analysis,Data Processing And Interpretation,High Content Screening,Laser Capture Microdissection,Microscopy,Multiphoton Microscopy,Optical Imaging,Slide Scanning,Whole Slide Imaging.
Proper citation: Harvard Center for Biological Imaging Core Facility (RRID:SCR_018673) Copy
https://www.uhcancercenter.org/research/shared-resources/genomics-and-bioinformatics
Core offers central service that uses genomic technologies combined with expert data analysis.Provides genomic analyses and bioinformatics as well as technical and scientific consultation,collaboration and initial data interpretation to all UH faculty with priority given to Cancer Center members with federal funding for cancer related projects. Offers expertise in molecular biology, genetics, genomics and bioinformatics, and can provide project planning, advice, and troubleshooting at all phases of the project.Genomic analysis services include DNA/RNA isolation, plating, and quality analysis, custom genotyping, Real-Time qPCR-based gene expression, copy number and methylation assays, pyrosequencing, Affymetrix and Illumina microarray based assays,Next Generation Sequencing on NextSeq500, iSeq100, NanoString nCounter analysis.
Proper citation: University of Hawaii at Manoa Cancer Center Genomics and Bioinformatics Shared Resource Core Facility (RRID:SCR_019085) Copy
http://psf.cobre.ku.edu/cores/bnmrl/about
NMR Laboratory maintains two high field NMR spectrometers in support of structural and dynamics studies of biomolecules. Its capabilities include determining high resolution structures, biological macromolecules, elucidation and structural mapping of protein-protein, protein-nucleic acid, protein-peptide, protein-drug interactions, and studies of dynamics of proteins and their complexes in solution. Laboratory staff provide advice,consultation, training,assistance and complete structure elucidation services.Staff is responsible for maintenance, upgrades, implementation of new NMR pulse sequences, and assisting local and remote users with technical problems.Equipped with Bruker Avance 800 MHz NMR instrument fitted with TCI cryoprobe and Bruker Avance III 600 MHz with variety of probes.
Proper citation: Kansas University Lawrence Biomolecular NMR Laboratory Core Facility (RRID:SCR_018671) Copy
https://ninc.centreforbrainhealth.ca
Core facility at Djavad Mowafaghian Centre for Brain Health located at University of British Columbia Hospital on Point Grey campus in Vancouver, BC. NINC offers access to advanced imaging systems and computational resources including confocal and two photon microscopes,live cell imaging, optical coherence tomography, training students and researchers in neuroscience research techniques.
Proper citation: University of British Columbia NeuroImaging and NeuroComputation Centre Core Facility (RRID:SCR_019086) Copy
https://www.urmc.rochester.edu/rochester-human-immunology-center.aspx
Designed to enhance multi-disciplinary research initiatives catalyzing key clinical and basic immunology research in vaccines, HIV/AIDS, autoimmunity, allergy/asthma, transplantation as well as cancer immunology.Provides expertise in multichromatic flow cytometry (immunophenotyping, antigen-specific intracellular cytokine staining and cell sorting), T and B cell Elispot, Fluorispot, T regulatory cell assays, magnetic bead selection of cell populations, and Luminex multiplexed bead array assays.Provides specialized clinical specimen analysis services for clinical studies or contracts.
Proper citation: Rochester University Human Immunology Center Core Facility (RRID:SCR_018670) Copy
http://www.biotech.ufl.edu/bioinformatics/
Core offers bioinformatics consulting and data analysis services to help researchers analyze and understand large data sets acquired from next generation sequencing and array based technologies.Bioinformatics staff members have extensive experience in bioinformatics, genomics, transcriptomics and translational informatics in plant, animal and microbial systems. Expertise includes big data analysis, statistical analysis, software development and high performance computing.
Proper citation: University of Florida ICBR Bioinformatics Core Facility (RRID:SCR_019120) Copy
Core facility is equipped with instrumentation to support proteomic and metabolomic research, as well as equipment for materials characterization. Key instruments include a Bruker 700MHz NMR, two Bruker XRDs (Powder and Crystal), and Bruker Micro ToF mass spectrometer.
Proper citation: Claflin University Molecular Science Research Center Core Facility (RRID:SCR_018836) Copy
https://www.med.unc.edu/neuroscience/core-facilities/neuro-microscopy/
Microscopy Core for high resolution imaging and aims to make this technology accessible to neuroscientists and other scientific researchers.Provides advanced systems for cellular and molecular imaging of in vitro and in vivo samples, implements new imaging technologies, particularly related to real time and tissue clearing based imaging of neurodevelopment and neural functions, offers training, consultation, data analysis, image processing, and centralized technical expertise.
Proper citation: University of North Carolina at Chapel Hill School of Medicine Neuroscience Microscopy Core Facility (RRID:SCR_019060) Copy
https://fralinlifesci.vt.edu/core-services/mass-spectrometry-incubator.html
Facility supports Virginia Tech's research infrastructure as mass spectrometry analysis and education center. Provides training in sample preparation, instrument operation and data analysis, with strong emphasis on metadata and analytical requirements for publication of metabolomic and proteomic results.
Proper citation: Virginia Tech Mass Spectrometry Incubator Core Facility (RRID:SCR_017956) Copy
http://www.umass.edu/ials/mass-spectrometry
Core offers instrumentation for characterizing elements and compounds across the entire mass range. Specialized mass spectrometers encompass variety of ionization techniques and separation devices to cover wide range of analytical capabilities.Facility accepts samples and will perform requested analysis.Offers training to conduct experimentation. Instruments include Bruker SolariX FT-ICR,Bruker MicroTOF II ESI,Bruker MicroFLEX MALDI,JEOL MStation sector with EI and FAB sources.
Proper citation: UMass Amherst Mass Spectrometry Core Facility (RRID:SCR_019063) Copy
http://www.biotech.ufl.edu/cytometry/
Cytometry core offers project consulting, experimental design and optimization as well as data analysis services. Provides tools and staff expertise for both live and fixed cell analysis. Provides FACS ARIA and SONY SH800 sorters to help users sort cells of interest. Offers microscopes for self service users. Microscope brands include Leica SP5 Confocal, Nikon Multiphoton Confocal system, Nikon Live cell Imaging platform, Olympus spinning Disk Confocal instruments, Keyence BZX800.
Proper citation: University of Florida ICBR Cytometry Core Facility (RRID:SCR_019119) Copy
https://medicine.iu.edu/research/support/service-cores/chemical-genomics
Core provides collection of diversity-oriented, drug-like, and natural small molecules in non-redundant libraries, variety of automated liquid handling and assay detection systems such as EnVision Multiplate reader and ArrayScan HCA System, modern equipment for medicinal and analytical chemistry including NMR, LC-QTOF MS, HPLC, Peptide Synthesizer, and sophisticated chemoinformatics tools. Besides traditional high-throughput screening and hit compound optimization services, newly adapted technologies include arrayed CRISPR screening, phage display, and SAR by NMR.
Proper citation: Indiana University School of Medicine Chemical Genomics Core Facility (RRID:SCR_018785) Copy
http://www.pasteur.fr/biophysics
Provides services and instrumentation for characterization of biological macromolecules with technical and methodological expertise. Provides characterization of macromolecules including shape, folding, stability auto-association,and they interactions including stoichiometry,thermodynamic and kinetic parameters.
Proper citation: Pasteur Institute Biophysics of Macromolecules and their Interactions Core Facility (RRID:SCR_018267) Copy
Established to produce immortalized cell lines from human blood (EBV transformations). Offers genomics applications for single cells, including RNA-seq, gene expression profiling by qPCR and DNA amplification for whole-genome or targeted (exome or PCR-based analysis) through 10x Genomics Chromium platform (similar to Drop Seq). Offers custom genotyping to analyze short tandem repeats, variable number tandem repeats and single nucleotide polymorphisms.
Proper citation: Johns Hopkins University School of Medicine Genetic Resources Core Facility (RRID:SCR_018669) Copy
https://animalcare.umich.edu/business-services/ulam-pathology-core/
Our core is affiliated with the Unit for Laboratory Animal Medicine (ULAM) at the University of Michigan-Ann Arbor. We provide animal pathology services in support of non-GLP preclinical, translational, or basic science studies. Services include histology preparation, immunohistochemistry, animal hematology and serum chemistry assays, digital slide scanning/image analysis, and pathology interpretation by board-certified veterinary pathologists. Our core mission is to reduce bias and increase rigor within non-GLP animal research by providing high quality, documented, pathology support that may not be otherwise accessible within individual laboratories. Our laboratory maintains internal SOPs, documented quality control practices, and accountability/chain-of-custody records for all submissions. Additionally, we participate in an external quality control program through the Veterinary Laboratory Association.
Proper citation: University of Michigan ULAM Pathology Core Facility (RRID:SCR_018823) Copy
https://childrenshospital.corefacilities.org/service_center/show_external/3145
Core with advanced instrumentation in Light and Electron Microscopy.Core provides confocal, multiphoton microscopy,electron microscopy,image analysis.
Proper citation: Harvard Medical School PCMM Microscopy Core Facility (RRID:SCR_018822) Copy
https://vbrn.org/proteomics-services/
Provides central resource of mass spectrometry based proteomics technologies to identify, characterize and quantify target proteins in various biological and biomedical samples. Provides mass spectrometry expertise for analyzing proteins and peptides for proteomics studies, support for data analysis from proteomics measurements, training in proteomics methods, and experimental design.
Proper citation: Vermont University Proteomics Core Facility (RRID:SCR_018667) Copy
https://www.colorado.edu/lmcf/
Provides access to instruments and training. Instruments including Dell Precision 7910 Analysis PC,Leica DMRXA Upright Widefield Microscope, Nikon E600 Upright Widefield Microscope, Nikon N-SIM structured illumination super-resolution and A1 laser scanning confocal microscope, Nikon Inverted Spinning Disk Confocal Microscope, Zeiss 510 Laser Scanning Confocal Microscope.
Proper citation: Colorado University at Boulder Light Microscopy Core Facility (RRID:SCR_018993) Copy
Core helps researchers investigate interactions between small molecules and biological systems by providing medicinal chemistry and chemical biology expertise and organic synthesis support.
Proper citation: Oregon Health and Science University Medicinal Chemistry Core Facility (RRID:SCR_019048) Copy
https://www.danforthcenter.org/our-work/core-facilities/phenotyping/
Core provides instruments including Scanalyzer 3D platform which consists of multiple digital imaging chambers connected to controlled environment Conviron growth house by conveyor belt system, resulting in continuous imaging loop and enables repeatedly image plants at multiple points throughout time.RGB imaging allows visualization and quantification of plant color and structural morphology. Near-infrared (NIR) enables visualization and quantification of plant water-use efficiency.Watering and weighing stations are customizable to deliver water and nutrients on specified schedule by volume or weight. Standard phenotyping services include operation and maintenance of LemnaTec Scanalyzer system, as well as technical support and troubleshooting.
Proper citation: Donald Danforth Plant Science Center Phenotyping Core Facility (RRID:SCR_019049) Copy
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