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https://ki.mit.edu/sbc/nanocore

Provides instruments for materials and nanomaterials research and full service TEM and cryoTEM sample preparation and imaging. Conducts CLEM and cryoCLEM workflows utilizing cryoFluorescence, cryoSEM and cryoFIB with focus on bio samples.Provides equipment and expertise to work with nanomaterials for characterization and imaging purpose. Core imaging capabilities include high performance field emission transmission electron microscope equipped with STEM, EELS, EDS and cryo-imaging, high performance field emission scanning electron microscope and focused ion beam equipped with STEM and cryo-imaging, cryo-fluorescent confocal microscope for CLEM workflows, and atomic force microscope equipped with liquid cell. Instrumentation for material characterization includes high throughputdynamic light scattering, nanoparticle sizing and counting, and rheometry.

Proper citation: Massachusetts Institute of Technology Swanson Biotechnology Center Nanotechnology Materials Core Facility (RRID:SCR_018674) Copy   

•   Source: SciCrunch Registry

http://www.hcbi.fas.harvard.edu

Microscopy facility. Contains microscopes including confocal, super-resolution, multi-photon, light sheet, live cell imaging, high-content screening, slide scanning, laser dissection and macroscopy stations. Features wet lab space, eukaryotic and prokaryotic incubation, and access to nearby animal care facilities for wide range of species.Services include Cell Imaging,Confocal Microscopy,Consultations,Data Analysis,Data Processing And Interpretation,High Content Screening,Laser Capture Microdissection,Microscopy,Multiphoton Microscopy,Optical Imaging,Slide Scanning,Whole Slide Imaging.

Proper citation: Harvard Center for Biological Imaging Core Facility (RRID:SCR_018673) Copy   

•   Source: SciCrunch Registry

http://psf.cobre.ku.edu/cores/bnmrl/about

NMR Laboratory maintains two high field NMR spectrometers in support of structural and dynamics studies of biomolecules. Its capabilities include determining high resolution structures, biological macromolecules, elucidation and structural mapping of protein-protein, protein-nucleic acid, protein-peptide, protein-drug interactions, and studies of dynamics of proteins and their complexes in solution. Laboratory staff provide advice,consultation, training,assistance and complete structure elucidation services.Staff is responsible for maintenance, upgrades, implementation of new NMR pulse sequences, and assisting local and remote users with technical problems.Equipped with Bruker Avance 800 MHz NMR instrument fitted with TCI cryoprobe and Bruker Avance III 600 MHz with variety of probes.

Proper citation: Kansas University Lawrence Biomolecular NMR Laboratory Core Facility (RRID:SCR_018671) Copy   

•   Source: SciCrunch Registry

https://www.urmc.rochester.edu/rochester-human-immunology-center.aspx

Designed to enhance multi-disciplinary research initiatives catalyzing key clinical and basic immunology research in vaccines, HIV/AIDS, autoimmunity, allergy/asthma, transplantation as well as cancer immunology.Provides expertise in multichromatic flow cytometry (immunophenotyping, antigen-specific intracellular cytokine staining and cell sorting), T and B cell Elispot, Fluorispot, T regulatory cell assays, magnetic bead selection of cell populations, and Luminex multiplexed bead array assays.Provides specialized clinical specimen analysis services for clinical studies or contracts.

Proper citation: Rochester University Human Immunology Center Core Facility (RRID:SCR_018670) Copy   

•   Source: SciCrunch Registry

http://tools.thermofisher.com/content/sfs/manuals/cms_041850.pdf

Automated peptide synthesizer for chain assembly steps in solid phase peptide synthesis or FastMoc chemistry. Data is based on conductance or ultraviolet UV absorbance of reagent, solutions, and solvents in the synthesis cycle.

Proper citation: Thermo Fisher: Applied Biosystems: 433A Peptide Sequencer (RRID:SCR_018440) Copy   

•   Source: SciCrunch Registry

https://fralinlifesci.vt.edu/core-services/mass-spectrometry-incubator.html

Facility supports Virginia Tech's research infrastructure as mass spectrometry analysis and education center. Provides training in sample preparation, instrument operation and data analysis, with strong emphasis on metadata and analytical requirements for publication of metabolomic and proteomic results.

Proper citation: Virginia Tech Mass Spectrometry Incubator Core Facility (RRID:SCR_017956) Copy   

•   Source: SciCrunch Registry

https://medicine.iu.edu/research/support/service-cores/chemical-genomics

Core provides collection of diversity-oriented, drug-like, and natural small molecules in non-redundant libraries, variety of automated liquid handling and assay detection systems such as EnVision Multiplate reader and ArrayScan HCA System, modern equipment for medicinal and analytical chemistry including NMR, LC-QTOF MS, HPLC, Peptide Synthesizer, and sophisticated chemoinformatics tools. Besides traditional high-throughput screening and hit compound optimization services, newly adapted technologies include arrayed CRISPR screening, phage display, and SAR by NMR.

Proper citation: Indiana University School of Medicine Chemical Genomics Core Facility (RRID:SCR_018785) Copy   

•   Source: SciCrunch Registry

http://www.pasteur.fr/biophysics

Provides services and instrumentation for characterization of biological macromolecules with technical and methodological expertise. Provides characterization of macromolecules including shape, folding, stability auto-association,and they interactions including stoichiometry,thermodynamic and kinetic parameters.

Proper citation: Pasteur Institute Biophysics of Macromolecules and their Interactions Core Facility (RRID:SCR_018267) Copy   

•   Source: SciCrunch Registry

https://grcf.jhmi.edu/

Established to produce immortalized cell lines from human blood (EBV transformations). Offers genomics applications for single cells, including RNA-seq, gene expression profiling by qPCR and DNA amplification for whole-genome or targeted (exome or PCR-based analysis) through 10x Genomics Chromium platform (similar to Drop Seq). Offers custom genotyping to analyze short tandem repeats, variable number tandem repeats and single nucleotide polymorphisms.

Proper citation: Johns Hopkins University School of Medicine Genetic Resources Core Facility (RRID:SCR_018669) Copy   

•   Source: SciCrunch Registry

https://animalcare.umich.edu/business-services/ulam-pathology-core/

Our core is affiliated with the Unit for Laboratory Animal Medicine (ULAM) at the University of Michigan-Ann Arbor. We provide animal pathology services in support of non-GLP preclinical, translational, or basic science studies. Services include histology preparation, immunohistochemistry, animal hematology and serum chemistry assays, digital slide scanning/image analysis, and pathology interpretation by board-certified veterinary pathologists. Our core mission is to reduce bias and increase rigor within non-GLP animal research by providing high quality, documented, pathology support that may not be otherwise accessible within individual laboratories. Our laboratory maintains internal SOPs, documented quality control practices, and accountability/chain-of-custody records for all submissions. Additionally, we participate in an external quality control program through the Veterinary Laboratory Association.

Proper citation: University of Michigan ULAM Pathology Core Facility (RRID:SCR_018823) Copy   

•   Source: SciCrunch Registry

https://childrenshospital.corefacilities.org/service_center/show_external/3145

Core with advanced instrumentation in Light and Electron Microscopy.Core provides confocal, multiphoton microscopy,electron microscopy,image analysis.

Proper citation: Harvard Medical School PCMM Microscopy Core Facility (RRID:SCR_018822) Copy   

•   Source: SciCrunch Registry

https://vbrn.org/proteomics-services/

Provides central resource of mass spectrometry based proteomics technologies to identify, characterize and quantify target proteins in various biological and biomedical samples. Provides mass spectrometry expertise for analyzing proteins and peptides for proteomics studies, support for data analysis from proteomics measurements, training in proteomics methods, and experimental design.

Proper citation: Vermont University Proteomics Core Facility (RRID:SCR_018667) Copy   

•   Source: SciCrunch Registry

https://med.nyu.edu/research/scientific-cores-shared-resources/microscopy-laboratory

Core offers comprehensive light and electron microscopy technologies. Our scientists use light microscopes and electron microscopes at resolutions ranging from centimeters to angstroms, providing clear and detailed images.We assist at every stage of your experiment, offering research-design consultation and instrument training, as well as guidance in study execution, analysis, and presentation for publication.

Proper citation: New York University School of Medicine Langone Health Microscopy Laboratory Core Facility (RRID:SCR_017934) Copy   

•   Source: SciCrunch Registry

http://www.ohsu.edu/bbc

Core provides statistical and big data analysis support. Performs data analysis and manuscript preparation services in Biostatistics, such as statistical genetics, longitudinal, survival, and high-throughput/high-dimensional omics data analysis; and Bioinformatics, such as DNA- and RNA-seq alignment, single cell DNA- and RNA-seq analysis, variant calling, differential expression and pathway analysis, data integration, online data submission, and custom script writing. Provides training to lab staff to enable them to perform future analyses.

Proper citation: Oregon Health and Science University Bioinformatics and Biostatistics Core Facility (RRID:SCR_017946) Copy   

•   Source: SciCrunch Registry

https://cancer.dartmouth.edu/scientists-researchers/clinical-pharmacology

Supports Dartmouth Cancer Center investigators in design, performance, data analysis, and interpretation of pharmacology objectives in preclinical, clinical and epidemiological studies.

Proper citation: Dartmouth College Clinical Pharmacology Shared Resource Core Facility (RRID:SCR_000873) Copy   

•   Source: SciCrunch Registry

https://www.colorado.edu/facility/ems/

Core provides access to instruments including:FEI Tecnai 12 Spirit TEM, FEI Tecnai F20 (200kV) FEG-TEM 200kV FEG-TEM,Gatan US4000 4k x 4k CCD, bottom-mount,CryoTEM and electron tomography,High-resolution TEM;FEI Tecnai F20 (200kV) FEG-TEM,300kV FEG-TEM,Gatan US4000 4k x 4k CCD, bottom-mount,CryoTEM and electron tomography,High-resolution TEM,FEI/Phillips CM100 (100kV) TEM,100kV, tungsten TEM,2k x 2k AMT CCD, bottom-mount.

Proper citation: Colorado University at Boulder EM Services Core Facility (RRID:SCR_001432) Copy   

•   Source: SciCrunch Registry

https://genome.med.harvard.edu/

Provided core services include Sanger DNA Sequencing, Next Generation DNA Sequencing (Four Illumina MiSeqs, four Illumina NextSeq 500s and one Illumina NovaSeq 6000),Next Generation Automated Library Sample Prep (Perkin Elmer Sciclone Genomic, ChIP, RNAseq and other methods), Single Cell DNA and RNA-Seq (10X Genomics Chromium), Bioanalyzer Analysis DNA and RNA (Two Agilent 2100 BioAnalyzers and two Agilent 2200 TapeStations), Qiagen Qiacube Automated DNA / RNA Prep (single to multiple samples), Oligonucleotide Ordering (IDT Portal), Reagents and Supplies Ordering (multiple vendors / products). Facility web based Laboratory Information Management System provides users with access to order services and supplies as well as retrieve data and review and pay invoices all online.

Proper citation: Harvard Medical School Biopolymers Core Facility (RRID:SCR_007175) Copy   

•   Source: SciCrunch Registry

https://www.ohsu.edu/histopathology-core

Provides routine and customized histology and immunohistochemistry services critical for progress of biomedical research.

Proper citation: OHSU Histopathology Shared Resource Core Facility (RRID:SCR_009977) Copy   

•   Source: SciCrunch Registry

https://www.ohsu.edu/gene-profiling-shared-resource

Full service genomics facility providing research scientists and clinicians with services for RNA expression profiling, DNA variation analysis, and nucleic acid extraction.

Proper citation: OHSU Gene Profiling Shared Resource Core Facility (RRID:SCR_009975) Copy   

•   Source: SciCrunch Registry

https://www.ohsu.edu/multiscale-microscopy-core

Multiscale Microscopy Core at OHSU is electron microscopy core that provides services and training to academic and corporate users.

Proper citation: Oregon Health and Science University Multiscale Microscopy Core Facility (RRID:SCR_009969) Copy   

•   Source: SciCrunch Registry