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https://www.brown.edu/research/projects/superfund/cores/core-d

Core provides equipment and technical expertise for evaluation of molecular and morphological changes in cells, tissues, and organs following exposure to complex environmental contaminants. Provides equipment, including automated tissue processor, paraffin embedding center, two automated microtomes, cryostat, vibratome for soft-tissue sectioning, multiheaded light microscope with projection capabilities, system for laser capture microdissection, and slide scanner with analysis software for identification and quantification of morphological structures.Offers expertise in histopathological and immunocytochemial methods, including fixation, dehydration, embedding, sectioning, histological staining, immunolabeling, high-resolution imaging, and quantitative image analysis. Services in sample preparation, offers assistance in imaging and image analysis and provides consultation for ongoing or future research projects, training program for students and investigators who use centrally available equipment.

Proper citation: Brown University Molecular Pathology Core Facility (RRID:SCR_017898) Copy   

•   Source: SciCrunch Registry

https://www.igb.illinois.edu/corefacilities

Core for biological microscopy and image analysis. Offers high-end equipment,user training,ongoing support, including experiment design and data interpretation,twenty-four hour access Services,3D Printing, Transfer Files, Image Analysis,Histology,Instrument Training.

Proper citation: University of Illinois at Urbana-Champaign Core Facilities at IGB (RRID:SCR_017938) Copy   

•   Source: SciCrunch Registry

https://www.rankinbiomed.com/product/refurbished-american-optical-860-sliding-micrtome/

THIS REOURCE IS NO LONGER IN SERVICE. Documented on September 29,2023. Sliding microtome used for cutting hard objects such as bone, wood, frozen celloidin, and paraffin preparations. Cutting thickness is adjustable from 1 to 40 microns.

Proper citation: American Optical: 860 Sliding Microtome (RRID:SCR_018434) Copy   

•   Source: SciCrunch Registry

https://atagousa.corecommerce.com/PAL-10S-p358.html

Digital hand held pocket refractometer that measures urine specific gravity. It has measurement temperature of 10 to 35 C and sample volume of 0.3ml.

Proper citation: Atago: PAL-10S Pocket Refractometer (RRID:SCR_018439) Copy   

•   Source: SciCrunch Registry

https://www.sutter.com/manuals/P-2000_OpMan.pdf

Microprocessor controlled, CO2 laser based micropipette puller.Default configuration allows fabrication of micropipettes for intracellular recording, patch clamping, microinjection and microperfusion.Can store up to 100 separate programs, each consisting of up to 8 command lines. The five parameters set in each command line allow exquisite control of the micropipette taper geometry. Allows the use of wide range of glass diameters from 0.125 to 1.2 mm.

Proper citation: Sutter: P-2000 Laser Micropipette Puller (RRID:SCR_018640) Copy   

•   Source: SciCrunch Registry

http://edboyden.org/05.09.boyden.html

Laser tool that enables neurons to be optically silenced by pulses of yellow light, the light-activated chloride pump halorhodopsin (Halo), in a paper entitled Multiple-color optical activation, silencing, and desynchronization of neural activity, with single-spike temporal resolution. Temporally precise, noninvasive control of activity in well-defined neuronal populations is a long-sought goal of systems neuroscience. We adapted for this purpose the naturally occurring algal protein Channelrhodopsin-2, a rapidly gated light-sensitive cation channel, by using lentiviral gene delivery in combination with high-speed optical switching to photostimulate mammalian neurons. We demonstrate reliable, millisecond-timescale control of neuronal spiking, as well as control of excitatory and inhibitory synaptic transmission. This technology allows the use of light to alter neural processing at the level of single spikes and synaptic events, yielding a widely applicable tool for neuroscientists and biomedical engineers. The quest to determine how precise neural activity patterns mediate computation, behavior, and pathology would be greatly aided by a set of tools for reliably activating and inactivating genetically targeted neurons, in a temporally precise and rapidly reversible fashion. Having earlier adapted a light-activated cation channel, 1channelrhodopsin-2 (ChR2), for allowing neurons to be stimulated by blue light, we searched for a complementary tool that would enable optical neuronal inhibition, driven by light of a second color. Here we report that targeting the 1codon-optimized form of the light-driven chloride pump halorhodopsin from the archaebacterium Natronomas pharaonis (hereafter abbreviated Halo) to genetically-specified neurons enables them to be silenced reliably, and reversibly, by millisecond-timescale pulses of yellow light. We show that trains of yellow and blue light pulses can drive high-fidelity sequences of hyperpolarizations and depolarizations in neurons simultaneously expressing yellow light-driven Halo and blue light-driven ChR2, allowing for the first time manipulations of neural synchrony without perturbation of other parameters such as spiking rates. The Halo/ChR2 system thus constitutes a powerful toolbox for multichannel photoinhibition and photostimulation of virally or transgenically targeted neural circuits without need for exogenous chemicals, enabling systematic analysis and engineering of the brain, and quantitative bioengineering of excitable cells.

Proper citation: Channelrhodopsin-2 enables optical activation of neurons (RRID:SCR_008833) Copy   

•   Source: SciCrunch Registry

https://industry.nikon.com/en-us/products/x-ray-ct/xt-h-225-xt-h-320/

Provides insight into the inside of components and specimens, allowing users to visualize, analyze and measure complex internal geometry as well as surfaces, all non-destructively. Versatile microfocus CT system for high resolution inspection in R&D and failure analysis of components ranging from tiny plastic connectors up to aluminum castings.

Proper citation: Nikon: XT H 225 ST uCT system (RRID:SCR_023687) Copy   

•   Source: SciCrunch Registry

https://www.shoprainin.com/Pipettes/Single-Channel-Manual-Pipettes/Pipet-Lite-XLS-LTS/Pipet-Lite-LTS-Pipette-L-1000XLS%2B/p/17014382

Pipet-Lite™ XLS+ manual single-channel pipette, 100-1000 μL, uses LTS™ LiteTouch™ tips. Accurate and precise, ergonomic, autoclavable liquid end, rugged and durable (L-1000XLS+)

Proper citation: Rainin: Pipet-Lite LTS Pipette L-1000XLS+ (RRID:SCR_023894) Copy   

•   Source: SciCrunch Registry

https://www.shoprainin.com/Pipettes/Single-Channel-Manual-Pipettes/Pipet-Lite-XLS-LTS/Pipet-Lite-LTS-Pipette-L-200XLS%2B/p/17014391

Pipet-Lite™ XLS+ manual single-channel pipette, 20-200 μL, uses LTS™ LiteTouch™ tips. Accurate and precise, ergonomic, autoclavable liquid end, rugged and durable (L-200XLS+)

Proper citation: Rainin: Pipet-Lite LTS Pipette L-200XLS+ (RRID:SCR_023892) Copy   

•   Source: SciCrunch Registry

https://www.hitachi-keu.com/en-gb/iv/hv-f203gvscl.html

High resolution 1/1.8" 3 CCD Progressive Scan Color Camera with 1600 x 1200 pixel (UXGA) that is installed in the ZEISS Axioscan Z1 slide scanner. Integrated functions include electronic shutter from 1/30s to 1/100000s, Long term Integration up to 4s, AGC, external Trigger, Auto Shading, 6 Colour Masking, Frame-On-Demand Function, White Balance, AGC, Black Level Adjustment and Partial Scan Function.

Proper citation: Hitachi: 16-bit 3-CCD color camera HV-F203GV / HV-F203SCL (RRID:SCR_023888) Copy   

•   Source: SciCrunch Registry

https://www.sunchrom.de/en/products/maldi-ms-sample-preparation-2/suncollect-cf-spotter.html

CF-Spotter for MALDI-TOF microbial identification. Enables fast, efficient and reproducible sample preparation for MALDI-TOF microbial identification system and relieves your laboratory staff from tedious and time-consuming pipetting. Due to the non-contact application of the solutions, there is no carryover of the samples and the costs for consumables such as pipette tips are eliminated.

Proper citation: SunChrom: SunCollect CF Spotter (RRID:SCR_023906) Copy   

•   Source: SciCrunch Registry

https://www.sunchrom.de/en/products/maldi-ms-sample-preparation-2/sundigest.html

SunDigest incubation device provides fully software controlled and highly reproducible digestion process under standardized conditions. Feature includes Temperatures precisely adjustable between 4 °C and 50 °C; On-Tissue digestion process under optimal humidity; Preservation of spatial resolution; High performance digestion at 50 °C; Full digestion process control.Essential for reproducible results.

Proper citation: SunChrom: SunDigest Incubator (RRID:SCR_023905) Copy   

•   Source: SciCrunch Registry

https://www.leicabiosystems.com/en-be/histology-equipment/he-slide-stainers-special-stainers-coverslippers/leica-st5010/

Leica ST5010 Autostainer XL provides reproducible, consistent high quality staining, and increased workload throughput compared to manual staining.

Proper citation: Leica: Autostainer ST5010 XL (RRID:SCR_023957) Copy   

•   Source: SciCrunch Registry

https://www.beckman.com/flow-cytometry/clinical-flow-cytometers/navios-ex

Designed specifically for clinical laboratory NAVIOS EX 10-color flow cytometer delivers performance with improved sample traceability and reporting functions. Navios EX has two optional ready-to-use IVD reagent systems, the Navios Tetra System for simultaneous identification and enumeration of T, B and NK lymphocytes and the ClearLLab 10C System – the first FDA cleared and CE marked integrated leukemia and lymphoma immunophenotyping system.

Proper citation: Beckman Coulter: Navios EX flow cytometer (RRID:SCR_023797) Copy   

•   Source: SciCrunch Registry

https://mass-spec.stanford.edu/instruments

Agilent 6495C triple quadrupole LC/MS system increases capacity and sensitivity for targeted quantitation applications. Used to investigate more diverse and biologically relevant groups of targeted peptides, small molecules and metabolites in single experiment without compromising sensitivity, quantitative accuracy, or linearity.

Proper citation: Agilent: 6495 Triple Quadrupole LC/MS (RRID:SCR_023937) Copy   

•   Source: SciCrunch Registry

https://www.ambulatory-monitoring.com/pvt-192-psychomotor-vigilance-monitor

System includes PVT-192 monitor and REACT software. Used for reaction time testing for long-term, large-scale testing of vigilance, effects of sleep deprivation, and drug effects. Used for PVT test wherever measures of performance or sleepiness effects are needed.

Proper citation: Ambulatory Monitoring: Psychomotor Vigilance Task system (RRID:SCR_024213) Copy   

•   Source: SciCrunch Registry

https://www.zeiss.com/microscopy/us/products/confocal-microscopes/lsm-900-with-airyscan-2.html

Laser scanning confocal microscope for multiplex imaging and analysis., THIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 16,2025.

Proper citation: Zeiss: LSM 900 with Airyscan 2 (RRID:SCR_022263) Copy   

•   Source: SciCrunch Registry

https://www.licor.com/bio/odyssey-xf/

System includes Odyssey XF Imager and Empiria Studio Software for streamlined image acquisition, organization, and analysis of Western blots. Used for imaging near infrared and enhanced chemiluminescent Western blots, to detect multiple targets on same blot with two channel multiplex fluorescence, and document DNA gels.

Proper citation: LI-COR: Odyssey XF Imaging System (RRID:SCR_022510) Copy   

•   Source: SciCrunch Registry

https://www.bdbiosciences.com/en-us/products/instruments/flow-cytometers/research-cell-analyzers/bd-facsymphony-a5-se

Flow cytometer gains full visible spectrum coverage to collect all light emitted without need for filter changes, increasing dye flexibility and number of simultaneous colors. Uses unmix spectral data live in BD FACSDiva Software while retaining familiar compensation workflow. May improve resolution of difficult cells and populations using autofluorescence unmixing.

Proper citation: BD Biosciences: FACSymphony A5 SE Cell Analyzer (RRID:SCR_022674) Copy   

•   Source: SciCrunch Registry

https://www.scireq.com/flexivent/

System for small animal pulmonary function. Used for in vivo respiratory mechanics measurements. Goes beyond traditional resistance and compliance mechanics of pulmonary ventilation, and captures details about mechanical properties of conducting airways, terminal airways and parenchyma. Achieves sensitivity and reproducibility by precisely controlling experimental conditions.

Proper citation: SciReq: flexiVent system (RRID:SCR_022673) Copy   

•   Source: SciCrunch Registry