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URL: https://dx.doi.org/DOI:10.17504/protocols.io.wanfade

Authors: Zhao-Ting Meng, Fan Cui, Xue-Ying Li, Dong-Xin Wang

Summary: Total knee arthroplasty (TKA) is an important therapy for patients with serious knee osteoarthritis in order to improve quality of life and relieve pain. But a large number of patients who undergo this surgery experience moderate to severe postoperative pain. Previously, the investigators used single femoral nerve blockade combined with patient-controlled intravenous analgesia for postoperative analgesia for patients after TKA. Although this method provides acceptable analgesia, the incidence of opioid-associated side effects is relatively high. Low-dose epidural morphine is commonly used in postoperative analgesia after cesarean section, and the effect of single dose morphine lasts more than 20 hours, with low incidences of itching, nausea, vomiting, and respiratory depression. The investigators hypothesize that, for patients undergoing TKA, the addition of low-dose epidural morphine to single femoral nerve block and intravenous opioids can improve the postoperative analgesia, reduce the consumption of intravenous opioids and decrease opioid-associated side effects.

Associated Publications: Meng Z, Cui F, Li X, Wang D (2019) Epidural morphine improves postoperative analgesia in patients after total knee arthroplasty: A randomized controlled trial. PLoS ONE 14(7): e0219116. doi: 10.1371/journal.pone.0219116

Affiliations: Peking University First Hospital, Peking University First Hospital, Peking University First Hospital, Peking University First Hospital

External URL: https://doi.org/10.1371/journal.pone.0219116

Version: 2

Publication Date: 2018

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