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URL: https://dx.doi.org/DOI:10.17504/protocols.io.iq4cdyw

Authors: Chaoyi Deng, Xiao Wang, Qianmei Zhu, Yanming Kang, Jinlin Yang, Heng Wang

Summary: Backgroud:Since sedation and analgesia are widely accepted by patients and even considered by many gastroenterologists as an integral component of the endoscopic examination, opioids are indispensible in managing pain. Nalbuphine is as effective as morphine as a perioperative analgesic but has not been compared directly with sufentanil in clinical trials.Objectives：The aims of this study were to compare the efficacy and safety of nalbuphine with that of sufentanil in patients undergoing colonoscopy and to determine the optimal doses of nalbuphine in this indicationMethodsTwo hundred and forty consecutive patients aged 18–65 y with an American Society of Anesthesiologists classification of I–II and scheduled for colonoscopy were randomized to receive sufentanil 0.1 µg/kg (group S), nalbuphine 0.1 mg/kg (group N1), nalbuphine 0.15 mg/kg (group N2), or nalbuphine 0.2 mg/kg (group N3).  Baseline vital signs was recorded before the procedure. The four groups were monitored for propofol sedation using the bispectral index and pain relief was assessed using the Behavioral Pain Scale for non-intubated patients. The incidences of respiratory depression during endoscopy, nausea, vomiting, drowsiness, and abdominal distention were recorded in the post anesthesia care unit at 24 and 48 h after colonoscopy.

Associated Publications: Deng C, Wang X, Zhu Q, Kang Y, Yang J, Wang H (2017) Comparison of nalbuphine and sufentanil for colonoscopy: A randomized controlled trial. PLoS ONE 12(12): e0188901. doi: 10.1371/journal.pone.0188901

Affiliations: Department of Anesthesiology, Sichuan University West China Hospital, Chengdu, Sichuan, China., Department of Anesthesiology, Sichuan University West China Hospital, Chengdu, Sichuan, China., Department of Anesthesiology, Sichuan University West China Hospital, Chengdu, Sichuan, China., Department of Anesthesiology, Sichuan University West China Hospital, Chengdu, Sichuan, China., Department of Anesthesiology, Sichuan University West China Hospital, Chengdu, Sichuan, China., Department of Anesthesiology, Sichuan University West China Hospital, Chengdu, Sichuan, China.

External URL: https://doi.org/10.1371/journal.pone.0188901

Version: 1

Publication Date: 2017

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