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URL: https://dx.doi.org/DOI:10.17504/protocols.io.hwfb7bn

Authors: Sandra L. Ross, Marika Sherman, Patricia L. McElroy, Julie A. Lofgren, Gordon Moody, Patrick A. Baeuerle, Angela Coxon, Tara Arvedson

Summary: Protocol for detecting bystander cytotoxicity in mixed cultures of target-negative and target-positive cells treated with BiTE® antibody constructs. Two methods and one modification are described.

Associated Publications: Ross SL, Sherman M, McElroy PL, Lofgren JA, Moody G, Baeuerle PA, Coxon A, Arvedson T, Bispecific T cell engager (BiTE) antibody constructs can mediate bystander tumor cell killing. PLoS ONE 12(8). doi: 10.1371/journal.pone.0183390

Affiliations: Department of Oncology Research, Amgen Inc., Department of Oncology Research, Amgen Inc., Department of Oncology Research, Amgen Inc., Department of Oncology Research, Amgen Inc., Department of Oncology Research, Amgen Inc., Department of Oncology Research, Amgen Inc., Department of Oncology Research, Amgen Inc., Department of Oncology Research, Amgen Inc.

External URL: https://doi.org/10.1371/journal.pone.0183390

Version: 1

Publication Date: 2017

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