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URL: https://dx.doi.org/DOI:10.17504/protocols.io.bcndiva6

Authors: Ioannis Bellos, Vasilios Pergialiotis, Dimitrios Loutradis, Georgios Daskalakis

Summary: The present meta-analysis will assess the possible association of serum uric acid with the development of preeclampsia. Preeclampsia represents a serious pregnancy complication with increased fetal and maternal morbidity and mortality rates. Its incidence is estimated at approximately 5-8% of pregnancies, although presenting wide variance worldwide. Its pathophysiology is complex; however, it is hypothesized that the combination of poor trophoblast invasion with the release of angiogenic and pro-oxidant mediators into maternal circulation leads to generalized endothelial dysfunction. Prediction of the disease is necessary in order to provide measures of prevention, especially the administration of aspirin; nonetheless, the optimal screening model remains under investigation. All the available literature evidence regarding the prognostic utility of serum uric acid in preeclampsia is planned to be evaluated, by applying no date or language restrictions during the literature search. Result will be pooled by a quantitative meta-analytic approach, planning to subgroup outcomes on the basis of pregnancy trimester, disease severity and onset. The credibility of evidence will be evaluated under the GRADE framework.

Affiliations: National and Kapodistrian University of Athens, National and Kapodistrian University of Athens, National and Kapodistrian University of Athens, National and Kapodistrian University of Athens

Version: 1

Publication Date: 2020

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