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URL: https://dx.doi.org/DOI:10.17504/protocols.io.bb2siqee

Authors: Michelle E. Favre, Valerie Lim, Michael J. Falvo, Jorge M. Serrador

Summary: Cerebrovascular reactivity and cerebral autoregulation are two major mechanisms that regulate cerebral blood flow. Both mechanisms are typically assessed in either the supine or seated postures, but the effects of body position and sex differences remain unclear. This study examined the effects of body posture (supine vs. seated vs. standing) on cerebrovascular reactivity during hyper and hypocapnia and on cerebral autoregulation during spontaneous and slow-paced breathing in healthy men and women using transcranial Doppler ultrasonography of the middle cerebral artery. Results indicated significantly improved cerebrovascular reactivity in the supine compared with seated and standing postures (supine= 3.45±0.67, seated= 2.72±0.53, standing= 2.91±0.62%/mmHg, PP. These data highlight the importance of making comparisons within the same body position to ensure there is not a confounding effect of posture.

Associated Publications: Favre ME, Lim V, Falvo MJ, Serrador JM (2020) Cerebrovascular reactivity and cerebral autoregulation are improved in the supine posture compared to upright in healthy men and women. PLoS ONE 15(3): e0229049. doi: 10.1371/journal.pone.0229049

Affiliations: Department of Pharmacology, Physiology and Neuroscience, Rutgers Biomedical and Health Sciences, Newark, NJ, USA, Department of Pharmacology, Physiology and Neuroscience, Rutgers Biomedical and Health Sciences, Newark, NJ, USA, Department of Pharmacology, Physiology and Neuroscience, Rutgers Biomedical and Health Sciences, Newark, NJ, USA; Department of Physical Medicine and Rehabilitation, Rutgers Biomedical and Health Sciences, Newark, NJ, USA; War Related Illness and Injury Study Center, Department of Veterans Affairs, East Orange, NJ, USA, Department of Pharmacology, Physiology and Neuroscience, Rutgers Biomedical and Health Sciences, Newark, NJ, USA; War Related Illness and Injury Study Center, Department of Veterans Affairs, East Orange, NJ, USA; Department of Cardiovascular Electronics, National University of Ireland Galway, Galway, Ireland

External URL: https://doi.org/10.1371/journal.pone.0229049

Version: 1

Publication Date: 2020

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