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Jacob Kirkland 2019. Top2 Chromatin Accessibility by Etoposide Cross-linking. protocols.io https://dx.doi.org/10.17504/protocols.io.2rngd5eCopy Citation Copied
URL: https://dx.doi.org/DOI:10.17504/protocols.io.2rngd5e
Authors: Jacob Kirkland
Summary: The best way to determine TOP2 specific accessibility to chromatin is via etoposide treatment, which leads to a covalent cross-link between TOP2 proteins and DNA, that can only occur where TOP2 proteins have access to DNA. TOP2 cross-linking to DNA has previously been shown to require DNA accessibility and chromatin regulators that alter DNA accessibility (Dykhuizen and Hargreaves et al. Nature 2013, Miller et al. NSMB 2017).
Affiliations: Stanford University
Version: 1
Publication Date: 2019
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