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URL: http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=155260364
Proper Citation: RRID:RRRC_00970
Description: Rattus norvegicus with name SD-Tg(Cyp3a23-3a1-Cyp3A4*-Cas9)SynblRrrc from RGD.
Species: Rattus norvegicus
Notes: rat strain in which the rat Cyp3a1 gene (Cyp3a23-3a1, RGD:628626) was inactivated by insertion of a human CYP3A4 minigene (Cyp3A4*) and the linked rat Cyp3a2 locus was simultaneously mutated by CRISPR-mediated indel introduction. Strain contains Indel 8 at the Rat 3A2 locus (55 kb away), The CYP3A4 minigene included a CRISPR/Cas9 gene drive element to enable super-Mendelian inheritance. Strain contains and Active Genetic cassette which encodes a gRNA targeting the Rat 3A1 and 3A2 translation initiation site. ROBUST AND EFFICIENT ACTIVE GENETICS GENE CONVERSION IN THE RAT AND MOUSE Chenyen Lai, Oscar Alvarez, Kristen Read, Don van Fossan,Christopher M Conner, Shannon Xaing-Ru Xu, Dale O. Cowley, Valentino Gantz, David R. Webb, Kurt Jarnagin URL: Doi:10.1101/2022.08.30.505951 URL: Doi:10.1101/2022.08.30.505951 URL: URL: Doi:10.1101/2022.08.30.505951 Rat Resource and Research Center
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Source: Integrated Animals
Source Database: Rat Resource and Research Center (RRRC)
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