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URL: https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=38501086
Proper Citation: RRID:RGD_38501086
Description: Rattus norvegicus with name SD-Bmpr2em1Ang+/- from RGD.
Species: Rattus norvegicus
Notes: BMPR2-deficient rats were generated by using zinc-finger nucleases (Sigma, St. Louis, MO). The mRNA encoding mRNA at 5 ng/μL encoding a pair of zinc-finger nucleases recognizing rat BMPR2 sequences was injected to the cytoplasm of Sprague-Dawley zygotes. A rat line with a heterozygous 140 base pairs deletion in the first exon (BMPR2Δ140Ex1/+ rats) was chosen for this study becauseit displayed an intense pulmonary vascular remodeling at 3 months of life that was absent in the wild-type littermates.
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Source: Integrated Animals
Source Database: Rat Genome Database (RGD)
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