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URL: https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=155260367
Proper Citation: RRID:RGD_155260367
Description: Rattus norvegicus with name SD-Tg(Cyp2e1-CYP2E1*-Cas9)Synbl from RGD.
Species: Rattus norvegicus
Notes: rat strain in which the rat Cyp2e1 gene is humanized by insertion of a human CYP2E1 minigene (CYP2E1*) insert at the native start codon. The insert also included a CRISPR/Cas9 gene drive element to enable super-Mendelian inheritance of the modified allele when crossed to a rat expressing Cas9 in the germline. ROBUST AND EFFICIENT ACTIVE GENETICS GENE CONVERSION IN THE RAT AND MOUSE Chenyen Lai, Oscar Alvarez, Kristen Read, Don van Fossan,Christopher M Conner, Shannon Xaing-Ru Xu, Dale O. Cowley, Valentino Gantz, David R. Webb, Kurt Jarnagin URL: Doi:10.1101/2022.08.30.505951 URL: Doi:10.1101/2022.08.30.505951 URL: URL: Doi:10.1101/2022.08.30.505951 Donated to Rat Resource & Research Center
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Source: Integrated Animals
Source Database: Rat Genome Database (RGD)
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