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URL: https://www.mmrrc.org/catalog/sds.php?mmrrc_id=44051
Proper Citation: RRID:MMRRC_044051-UCD
Description: Mus musculus with name B6J.Cg-Ptprctm1Holm Tg(ITGAL-Ptprca)BRasch/Mmucd from MMRRC.
Species: Mus musculus
Notes: Research areas: Developmental Biology, Hematology, Immunology and Inflammation, Models for Human Disease; Mutation Type: Targeted Mutation ; Collection:
Phenotype: spleen hyperplasia [MP:0000693]| thymus hyperplasia [MP:0000708]| decreased thymocyte number [MP:0000715]| increased T cell derived lymphoma incidence [MP:0002024]| abnormal T cell differentiation [MP:0002145]| abnormal lymphopoiesis [MP:0002401]| abnormal B cell number [MP:0002458]| decreased T cell number [MP:0005018]| increased double-negative T cell number [MP:0005090]| decreased double-positive T cell number [MP:0005092]| decreased CD4-positive [MP:0008075]| alpha beta T cell number [MP:0008079]| abnormal T cell differentiation [MP:0002145]| abnormal interferon level [MP:0008750]| altered susceptibility to infection induced morbidity/mortality [MP:0009785]| decreased susceptibility to viral infection induced morbidity/mortality [MP:0009790]| increased susceptibility to viral infection induced morbidity/mortality [MP:0009791]| abnormal NK cell physiology [MP:0010766]
Affected Gene: |Ptprc||||Ptprc
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Source: Mutant Mouse Resource and Research Center (RRID:SCR_002953)
Description: National public repository system for mutant mice. Archives and distributes scientifically valuable spontaneous and induced mutant mouse strains and ES cell lines for use by biomedical research community. Includes breeding/distribution facilities and information coordinating center. Mice strains are cryopreserved, unless live colony must be established. Live mice are supplied from production colony, from colony recovered from cryopreservation, or via micro-injection of cell line into host blastocysts. MMRRC member facilities also develop technologies to improve handling of mutant mice, including advances in assisted reproductive techniques, cryobiology, genetic analysis, phenotyping and infectious disease diagnostics.
URL: http://www.mmrrc.org/
Source Database: Mutant Mouse Resource and Research Center (MMRRC)
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