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URL: https://www.mmrrc.org/catalog/sds.php?mmrrc_id=41405
Proper Citation: RRID:MMRRC_041405-UCD
Description: Mus musculus with name B6J.Cg-Ikbkgtm1Dln Tnftm1Gkl/Mmucd from MMRRC.
Species: Mus musculus
Notes: Research areas: Apoptosis, Cell Biology, Dermatology, Developmental Biology, Hematology, Immunology and Inflammation, Models for Human Disease, Neurobiology; Mutation Type: Targeted Mutation ; Collection:
Phenotype: increased bone mineral density [MP:0000062]| abnormal trabecular bone morphology [MP:0000130]| increased leukocyte cell number [MP:0000218]| increased neutrophil cell number [MP:0000219]| abnormal Peyer's patch morphology [MP:0000696]| abnormal spermatogenesis [MP:0001156]| decreased body weight [MP:0001262]| abnormal vasodilation [MP:0001613]| abnormal inflammatory response [MP:0001845]| decreased inflammatory response [MP:0001876]| abnormal glucose homeostasis [MP:0002078]| premature death [MP:0002083]| abnormal lipid homeostasis [MP:0002118]| abnormal lymph node B cell domain morphology [MP:0002344]| abnormal spleen marginal sinus morphology [MP:0002363]| abnormal Peyer's patch follicle morphology [MP:0002389]| abnormal Peyer's patch germinal center morphology [MP:0002391]| abnormal Peyer's patch T cell area morphology [MP:0002392]| decreased susceptibility to bacterial infection [MP:0002411]| increased susceptibility to bacterial infection [MP:0002412]| abnormal macrophage physiology [MP:0002451]| decreased circulating triglyceride level [MP:0002644]| oligozoospermia [MP:0002687]| decreased circulating insulin level [MP:0002727]| dilated heart left ventricle [MP:0002753]| abnormal testes secretion [MP:0002782]| colitis [MP:0002816]| abnormal cytokine secretion [MP:0003009]| rheumatoid arthritis [MP:0003561]| oxidative stress [MP:0003674]| abnormal lymphocyte physiology [MP:0003945]| abnormal spermiation [MP:0004182]| decreased incidence of tumors by chemical induction [MP:0004502]| decreased susceptibility to experimental autoimmune encephalomyelitis [MP:0004800]| decreased testis weight [MP:0004852]| abnormal testis physiology [MP:0004884]| increased osteoblast cell number [MP:0004988]| increased lymphocyte cell number [MP:0005013]| increased susceptibility to parasitic infection [MP:0005027]| cachexia [MP:0005150]| abnormal mesenteric lymph node morphology [MP:0005232]| abnormal fat pad morphology [MP:0005334]| decreased susceptibility to autoimmune disorder [MP:0005351]| decreased percent body fat/body weight [MP:0005459]| decreased circulating glucose level [MP:0005560]| decreased ventricle muscle contractility [MP:0005598]| decreased susceptibility to type IV hypersensitivity reaction [MP:0005616]| decreased circulating leptin level [MP:0005668]| decreased Peyer's patch number [MP:0008133]| small Peyer's patches [MP:0008135]| absent follicular dendritic cells [MP:0008201]| abnormal metallophilic macrophage morphology [MP:0008241]| abnormal osteoclast differentiation [MP:0008396]| abnormal spleen primary B follicle morphology [MP:0008471]| abnormal spleen follicular dendritic cell network [MP:0008473]| absent spleen germinal center [MP:0008474]| increased circulating tumor necrosis factor level [MP:0008553]| decreased circulating tumor necrosis factor level [MP:0008554]| increased tumor necrosis factor secretion [MP:0008560]| abnormal chemokine secretion [MP:0008722]| decreased susceptibility to endotoxin shock [MP:0008734]| increased susceptibility to endotoxin shock [MP:0008735]| cecum inflammation [MP:0009481]| decreased keratinocyte proliferation [MP:0009584]| prenatal lethality [MP:0011101]| incomplete penetrance [MP:0013486]| decreased Paneth cell number [MP:0030466]
Affected Gene: Tnf||Ikbkg|
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Warning. Researchers have noted that this genotype does not sufficiently model human cherubism.
Source: Mutant Mouse Resource and Research Center (RRID:SCR_002953)
Description: National public repository system for mutant mice. Archives and distributes scientifically valuable spontaneous and induced mutant mouse strains and ES cell lines for use by biomedical research community. Includes breeding/distribution facilities and information coordinating center. Mice strains are cryopreserved, unless live colony must be established. Live mice are supplied from production colony, from colony recovered from cryopreservation, or via micro-injection of cell line into host blastocysts. MMRRC member facilities also develop technologies to improve handling of mutant mice, including advances in assisted reproductive techniques, cryobiology, genetic analysis, phenotyping and infectious disease diagnostics.
URL: http://www.mmrrc.org/
Source Database: Mutant Mouse Resource and Research Center (MMRRC)
The NIDDK Information Network (dkNET) serves the needs of basic and clinical investigators by providing seamless access to large pools of data and research resources relevant to the mission of The National Institute of Diabetes Digestive and Kidney Diseases (NIDDK). dkNET is hosted at University of California San Diego, and is supported by NIH NIDDK grant U24DK097771.
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