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Proper Citation: RRID:MGI:5563103
Description: Allele Detail: Targeted This is a legacy resource.
Species: Mus musculus
Notes: Allele Detail: Targeted This is a legacy resource.
Phenotype: abnormal T-helper 2 physiology, enlarged lymph nodes, dermatitis, abnormal T-helper 2 cell differentiation, abnormal lymph organ size, abnormal lymphopoiesis, abnormal regulatory T cell physiology, decreased CD4-positive, alpha beta T cell number, increased interleukin-13 secretion, increased IgE level, increased IgA level, increased CD8-positive, alpha-beta T cell number, increased CD4-positive, alpha beta T cell number, increased interleukin-5 secretion, abnormal interleukin secretion, increased interleukin-10 secretion, increased inflammatory response, increased leukocyte cell number, increased eosinophil cell number, increased interleukin-4 secretion, increased IgG1 level, increased interleukin-17 secretion, abnormal immunoglobulin level, weight loss, skin lesions, premature death, lung inflammation, increased regulatory T cell number, increased regulatory T cell apoptosis, immune system phenotype, enlarged spleen
Affected Gene: Itch, Foxp3
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No rating or validation information has been found for Itchtm1.1Alta/Itchtm1.1Alta; Foxp3tm4(YFP/icre)Ayr/Foxp3+.
No alerts have been found for Itchtm1.1Alta/Itchtm1.1Alta; Foxp3tm4(YFP/icre)Ayr/Foxp3+.
Source: Integrated Animals
Source Database: MGI, Mouse Genome Informatics MGI
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