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URL: https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=155260361
Proper Citation: RRID:RGD_155260361
Description: Rattus norvegicus with name SD-Tg(Sycp1-Cas9-eGFP)SynblRrrc from RGD.
Species: Rattus norvegicus
Notes: This project entailed generation of a novel rat strain in which a P2A-Cas9-T2A-EGFP coding sequence was inserted at the stop codon of the rat Sycp1 gene for co-expression of Cas9 and EGFP under the control of the Sycp1 regulatory elements. Animals express Cas9 in the testis in the spermatogonial layer and in meiosis stages with 4N DNA content. Strain catalyzes high levels of Active Genetic Gene conversion when paired with certain Active Genetic cassettes. ROBUST AND EFFICIENT ACTIVE GENETICS GENE CONVERSION IN THE RAT AND MOUSE Chenyen Lai, Oscar Alvarez, Kristen Read, Don van Fossan,Christopher M Conner, Shannon Xaing-Ru Xu, Dale O. Cowley, Valentino Gantz, David R. Webb, Kurt Jarnagin URL: Doi:10.1101/2022.08.30.505951 from RRRC.
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Source: Integrated Animals
Source Database: Rat Genome Database (RGD)
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