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URL: https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=15017094
Proper Citation: RRID:RGD_15017094
Description: Rattus norvegicus with name Wpk -/- from RGD.
Species: Rattus norvegicus
Notes: The wpk mutation was first recognized in 1994 in a colony of outbred Wistar rats at Utrecht University (Utrecht, The Netherlands). In 1996, a breeding pair of test-proven heterozygotes were transferred to the University of Rotterdam (Rotterdam, The Netherlands), and a new subcolony was initiated. This colony has been maintained by brother-sister matings for more than five generations. Individuals heterozygous for the mutant allele were identified in each generation by test-crossing phenotypically normal offspring from known heterozygotes. A single C to T substitution in exon 12 was identified as the mutated allele in the Wpk rat. This mutation converts a proline to a leucine in the protein products(P394L).
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Source: Integrated Animals
Source Database: Rat Genome Database (RGD)
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