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URL: https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=126848794
Proper Citation: RRID:RGD_126848794
Description: Rattus norvegicus with name SHR-Zbtb16em1Ipcv+/- from RGD.
Species: Rattus norvegicus
Notes: TALEN was used to target Zbtb16 (Plzf )in the SHR and one founder with a deletion of G at position 93 of the coding sequence (c.93delG) was identified. That deletion resulted in a frameshift downstream glycine 31 (p.Gly31fs). The frameshift mutation caused the incorporation of 20 aberrant amino acids downstream of the deleted G, followed by a stop codon. The founder was bred with SHR to generate more heterozygous animals. The homozygous animals die perinatally because of multiple developmental abnormalities.
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Source: Integrated Animals
Source Database: Rat Genome Database (RGD)
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