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URL: https://www.mmrrc.org/catalog/sds.php?mmrrc_id=50929
Proper Citation: RRID:MMRRC_050929-MU
Description: Mus musculus with name B10.Cg-Tg(DMD)72Thoen Dmdmdx/DuaMmmh from MMRRC.
Species: Mus musculus
Notes: Research areas: Models for Human Disease; Mutation Type: Transgenic ; Collection:
Phenotype: kyphosis [MP:0000160]| increased monocyte cell number [MP:0000220]| decreased neutrophil cell number [MP:0000222]| enlarged heart [MP:0000274]| abnormal myocardial fiber morphology [MP:0000278]| decreased granulocyte number [MP:0000334]| abnormal hindlimb morphology [MP:0000556]| absent CD8-positive [MP:0000727]| alpha-beta T cells [MP:0000729]| abnormal myogenesis [MP:0000733]| abnormal muscle development [MP:0000745]| tremors [MP:0000746]| weakness [MP:0000747]| muscle weakness [MP:0000748]| progressive muscle weakness [MP:0000749]| muscle degeneration [MP:0000750]| abnormal muscle regeneration [MP:0000751]| myopathy [MP:0000752]| dystrophic muscle [MP:0000759]| abnormal skeletal muscle morphology [MP:0000761]| thin diaphragm muscle [MP:0001053]| abnormal neuromuscular synapse morphology [MP:0001262]| decreased body weight [MP:0001263]| weight loss [MP:0001264]| increased body size [MP:0001265]| decreased body size [MP:0001402]| hypoactivity [MP:0001405]| impaired coordination [MP:0001406]| abnormal gait [MP:0001407]| short stride length [MP:0001504]| abnormal posture [MP:0001515]| abnormal grip strength [MP:0001732]| postnatal growth retardation [MP:0001853]| heart inflammation [MP:0001921]| reduced fertility [MP:0001923]| reduced female fertility [MP:0001951]| abnormal breathing pattern [MP:0001953]| respiratory failure [MP:0002066]| abnormal motor capabilities/coordination/movement [MP:0002083]| premature death [MP:0002106]| abnormal muscle physiology [MP:0002108]| abnormal muscle morphology [MP:0002109]| abnormal limb morphology [MP:0002269]| muscular atrophy [MP:0002279]| abnormal diaphragm morphology [MP:0002280]| abnormal intercostal muscle morphology [MP:0002795]| dilated cardiomyopathy [MP:0002833]| increased heart weight [MP:0002837]| dystrophic cardiac calcinosis [MP:0002841]| impaired skeletal muscle contractility [MP:0002899]| fatigue [MP:0002953]| thick ventricular wall [MP:0003061]| decreased aerobic running capacity [MP:0003084]| abnormal skeletal muscle fiber morphology [MP:0003105]| abnormal heart atrium morphology [MP:0003141]| cardiac fibrosis [MP:0003155]| abnormal telomere length [MP:0003157]| impaired muscle relaxation [MP:0003199]| calcified muscle [MP:0003358]| abnormal hypaxial muscle morphology [MP:0003393]| decreased cardiac output [MP:0003790]| absent CD4-positive [MP:0003833]| alpha beta T cells [MP:0003851]| decreased satellite cell number [MP:0003852]| skeletal muscle interstitial fibrosis [MP:0003884]| skeletal muscle necrosis [MP:0004036]| decreased macrophage cell number [MP:0004087]| abnormal muscle relaxation [MP:0004089]| abnormal muscle fiber morphology [MP:0004121]| dilated sarcoplasmic reticulum [MP:0004142]| abnormal sarcolemma morphology [MP:0004145]| abnormal muscle tone [MP:0004174]| abnormal muscle electrophysiology [MP:0004232]| abnormal spine curvature [MP:0004248]| decreased muscle weight [MP:0004262]| abnormal epaxial muscle morphology [MP:0004510]| abnormal physical strength [MP:0004564]| myositis [MP:0004566]| enlarged myocardial fiber [MP:0004597]| myocardial fiber degeneration [MP:0004703]| increased susceptibility to noise-induced hearing loss [MP:0004818]| abnormal vertebral column morphology [MP:0004819]| increased skeletal muscle mass [MP:0004973]| decreased skeletal muscle mass [MP:0005015]| increased regulatory T cell number [MP:0005017]| increased T cell number [MP:0005018]| decreased B cell number [MP:0005137]| decreased T cell number [MP:0005140]| increased growth hormone level [MP:0005165]| decreased cardiac muscle contractility [MP:0005294]| increased susceptibility to injury [MP:0005330]| abnormal heart ventricle morphology [MP:0005425]| cardiomyopathy [MP:0005608]| increased macrophage cell number [MP:0005620]| cardiac interstitial fibrosis [MP:0006085]| abnormal muscle contractility [MP:0008327]| myocardial necrosis [MP:0008416]| abnormal corticotroph morphology [MP:0008560]| increased somatotroph cell size [MP:0008566]| increased tumor necrosis factor secretion [MP:0008663]| increased interferon-gamma secretion [MP:0008687]| increased interleukin-12 secretion [MP:0008699]| increased interleukin-2 secretion [MP:0008705]| increased interleukin-4 secretion [MP:0008837]| increased interleukin-6 secretion [MP:0008838]| increased transforming growth factor level [MP:0008866]| decreased transforming growth factor level [MP:0008874]| chromosomal instability [MP:0009398]| decreased physiological sensitivity to xenobiotic [MP:0009399]| abnormal skeletal muscle fiber size [MP:0009400]| increased skeletal muscle fiber size [MP:0009401]| decreased skeletal muscle fiber size [MP:0009402]| increased skeletal muscle fiber diameter [MP:0009403]| decreased skeletal muscle fiber diameter [MP:0009404]| increased variability of skeletal muscle fiber size [MP:0009405]| centrally nucleated skeletal muscle fibers [MP:0009406]| increased skeletal muscle fiber number [MP:0009410]| decreased skeletal muscle fiber number [MP:0009412]| abnormal skeletal muscle satellite cell proliferation [MP:0009413]| skeletal muscle fiber degeneration [MP:0009414]| skeletal muscle fiber atrophy [MP:0009415]| skeletal muscle fiber necrosis [MP:0009416]| skeletal muscle degeneration [MP:0009417]| cardiac muscle degeneration [MP:0009419]| skeletal muscle atrophy [MP:0009420]| skeletal muscle fibrosis [MP:0009461]| skeletal muscle endomysial fibrosis [MP:0010024]| skeletal muscle hypertrophy [MP:0010053]| increased total body fat amount [MP:0010090]| decreased grip strength [MP:0010106]| increased circulating creatine kinase level [MP:0010226]| abnormal circulating pyruvate kinase level [MP:0010227]| increased quadriceps weight [MP:0010238]| decreased quadriceps weight [MP:0010239]| increased skeletal muscle weight [MP:0010252]| decreased skeletal muscle weight [MP:0010254]| anterior subcapsular cataracts [MP:0010581]| nuclear cataracts [MP:0010632]| abnormal atrium myocardial trabeculae morphology [MP:0011086]| cardiac muscle necrosis [MP:0011952]| postnatal lethality [MP:0011966]| incomplete penetrance [MP:0011967]| decreased cardiac stroke volume [MP:0012106]| abnormal auditory brainstem response waveform shape [MP:0013237]| increased or absent threshold for auditory brainstem response [MP:0013467]| impaired exercise endurance [MP:0014143]| abnormal skeletal muscle regeneration [MP:0020309]| diaphragmitis [MP:0030428]
Affected Gene: DMD||Dmd|
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Source: Mutant Mouse Resource and Research Center (RRID:SCR_002953)
Description: National public repository system for mutant mice. Archives and distributes scientifically valuable spontaneous and induced mutant mouse strains and ES cell lines for use by biomedical research community. Includes breeding/distribution facilities and information coordinating center. Mice strains are cryopreserved, unless live colony must be established. Live mice are supplied from production colony, from colony recovered from cryopreservation, or via micro-injection of cell line into host blastocysts. MMRRC member facilities also develop technologies to improve handling of mutant mice, including advances in assisted reproductive techniques, cryobiology, genetic analysis, phenotyping and infectious disease diagnostics.
URL: http://www.mmrrc.org/
Source Database: Mutant Mouse Resource and Research Center (MMRRC)
The NIDDK Information Network (dkNET) serves the needs of basic and clinical investigators by providing seamless access to large pools of data and research resources relevant to the mission of The National Institute of Diabetes Digestive and Kidney Diseases (NIDDK). dkNET is hosted at University of California San Diego, and is supported by NIH NIDDK grant U24DK097771.
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