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URL: https://www.mmrrc.org/catalog/sds.php?mmrrc_id=50543
Proper Citation: RRID:MMRRC_050543-MU
Description: Mus musculus with name C57BL/6JMlcr-ApcMin/Mmmh (GM4) from MMRRC.
Species: Mus musculus
Notes: Research areas: ; Mutation Type: chemically induced mutation ; Collection:
Phenotype: absent mandible [MP:0000087]| lordosis [MP:0000162]| decreased hematocrit [MP:0000208]| increased cell proliferation [MP:0000351]| abnormal intestine morphology [MP:0000477]| abnormal intestinal epithelium morphology [MP:0000488]| abnormal crypts of Lieberkuhn morphology [MP:0000490]| rectal prolapse [MP:0000493]| abnormal intestinal mucosa morphology [MP:0000511]| abnormal mammary gland development [MP:0000628]| mammary gland hyperplasia [MP:0000630]| abnormal adrenal gland morphology [MP:0000639]| abnormal brain development [MP:0000913]| abnormal ovarian folliculogenesis [MP:0001130]| abnormal ovarian follicle morphology [MP:0001131]| absent mature ovarian follicles [MP:0001132]| absent corpus luteum [MP:0001134]| abnormal vagina epithelium morphology [MP:0001140]| decreased body weight [MP:0001262]| weight loss [MP:0001263]| increased metastatic potential [MP:0001272]| hyperlipidemia [MP:0001548]| increased circulating triglyceride level [MP:0001552]| increased circulating free fatty acid level [MP:0001554]| anemia [MP:0001577]| extended life span [MP:0001661]| abnormal digestive system physiology [MP:0001663]| abnormal embryo development [MP:0001672]| abnormal embryo size [MP:0001697]| decreased embryo size [MP:0001698]| postnatal growth retardation [MP:0001732]| increased mammary adenocarcinoma incidence [MP:0001883]| abnormal tumor incidence [MP:0002019]| increased tumor incidence [MP:0002020]| increased incidence of induced tumors [MP:0002021]| increased carcinoma incidence [MP:0002038]| increased colon adenoma incidence [MP:0002044]| decreased tumor incidence [MP:0002052]| decreased incidence of induced tumors [MP:0002053]| premature death [MP:0002083]| altered tumor susceptibility [MP:0002166]| abnormal hematopoietic system morphology/development [MP:0002396]| increased intestinal adenoma incidence [MP:0002404]| abnormal effector T cell morphology [MP:0002435]| hepatic steatosis [MP:0002628]| colitis [MP:0002816]| increased intestinal adenocarcinoma incidence [MP:0002957]| abnormal egg cylinder morphology [MP:0003085]| acrania [MP:0003104]| colon polyps [MP:0003269]| intestinal obstruction [MP:0003270]| melena [MP:0003292]| gastric polyps [MP:0003299]| increased hepatocellular carcinoma incidence [MP:0003331]| decreased tumor growth/size [MP:0003447]| abnormal tumor morphology [MP:0003448]| abnormal intestinal goblet cell morphology [MP:0003449]| increased tumor growth/size [MP:0003721]| decreased macrophage cell number [MP:0003884]| abnormal corticosterone level [MP:0003963]| aneuploidy [MP:0004024]| increased incidence of tumors by chemical induction [MP:0004499]| increased incidence of tumors by ionizing radiation induction [MP:0004500]| decreased incidence of tumors by chemical induction [MP:0004502]| ovary atrophy [MP:0004833]| abnormal large intestine crypts of Lieberkuhn morphology [MP:0004842]| uterus atrophy [MP:0004894]| decreased T cell number [MP:0005018]| cachexia [MP:0005150]| abnormal exocrine pancreas morphology [MP:0005220]| abnormal cell physiology [MP:0005621]| increased mammary adenoacanthoma incidence [MP:0006422]| intestine polyps [MP:0008011]| duodenum polyps [MP:0008012]| decreased NK cell number [MP:0008045]| abnormal DNA repair [MP:0008058]| enlarged mesenteric lymph nodes [MP:0008466]| increased pancreatic acinar cell carcinoma incidence [MP:0008780]| increased small intestinal crypt cell apoptosis [MP:0008800]| chromosomal instability [MP:0008866]| decreased physiological sensitivity to xenobiotic [MP:0008874]| abnormal DNA methylation [MP:0008877]| abnormal enterocyte proliferation [MP:0008883]| increased enterocyte apoptosis [MP:0008885]| adrenal gland hyperplasia [MP:0009078]| increased small intestine adenocarcinoma incidence [MP:0009309]| increased colon adenocarcinoma incidence [MP:0009314]| decreased splenocyte number [MP:0009339]| abnormal pregnancy [MP:0009661]| absent nipple [MP:0009733]| increased prostaglandin level [MP:0009814]| decreased prostaglandin level [MP:0009815]| increased tumor latency [MP:0009828]| embryonic lethality between implantation and placentation [MP:0009850]| abnormal tumor vascularization [MP:0010144]| decreased mammary gland tumor incidence [MP:0010269]| increased classified tumor incidence [MP:0010273]| increased gastrointestinal tumor incidence [MP:0010279]| increased mammary gland tumor incidence [MP:0010299]| increased salivary gland tumor incidence [MP:0010318]| increased adenoma incidence [MP:0010383]| altered tumor pathology [MP:0010639]| abnormal survival [MP:0010769]| perinatal lethality [MP:0011089]| complete penetrance [MP:0011092]| embryonic lethality [MP:0011096]| complete penetrance [MP:0011100]| embryonic lethality between implantation and somite formation [MP:0011109]| complete penetrance [MP:0011635]| preweaning lethality [MP:0012087]| complete penetrance [MP:0012136]| lethality throughout fetal growth and development [MP:0012424]| incomplete penetrance [MP:0012434]| abnormal mitochondrial crista morphology [MP:0012436]| absent midbrain [MP:0013795]| absent forebrain [MP:0020324]
Affected Gene: Apc
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Source: Integrated Animals
Source Database: Mutant Mouse Resource and Research Center (MMRRC)
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