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URL: https://www.mmrrc.org/catalog/sds.php?mmrrc_id=42059
Proper Citation: RRID:MMRRC_042059-JAX
Description: Mus musculus with name B6;129P2-Ptentm1Mak/Mmjax from MMRRC.
Species: Mus musculus
Notes: Research areas: Cancer, Developmental Biology; Mutation Type: Targeted Mutation ; Collection:
Phenotype: abnormal brain development [MP:0000913]| open neural tube [MP:0000929]| abnormal somite development [MP:0001688]| decreased embryo size [MP:0001698]| abnormal placenta morphology [MP:0001711]| abnormal allantois morphology [MP:0001726]| increased mammary adenocarcinoma incidence [MP:0001883]| increased tumor incidence [MP:0002020]| increased T cell derived lymphoma incidence [MP:0002024]| increased leukemia incidence [MP:0002026]| increased adrenal gland tumor incidence [MP:0002031]| increased carcinoma incidence [MP:0002038]| increased skin papilloma incidence [MP:0002051]| abnormal developmental patterning [MP:0002084]| abnormal embryonic tissue morphology [MP:0002085]| abnormal seminiferous tubule morphology [MP:0002216]| colon polyps [MP:0003269]| kinked neural tube [MP:0003400]| embryonic growth retardation [MP:0003984]| disorganized embryonic tissue [MP:0003988]| failure of initiation of embryo turning [MP:0004180]| increased incidence of tumors by ionizing radiation induction [MP:0004500]| enlarged allantois [MP:0004556]| increased endometrial carcinoma incidence [MP:0004868]| enlarged Peyer's patches [MP:0008136]| endometrium hyperplasia [MP:0009092]| failure of chorioallantoic fusion [MP:0009657]| increased skin squamous cell carcinoma incidence [MP:0009704]| increased mammary gland tumor incidence [MP:0010299]| increased hamartoma incidence [MP:0010306]| increased prostate gland tumor incidence [MP:0010357]| increased fibroadenoma incidence [MP:0010364]| embryonic lethality during organogenesis [MP:0011098]| complete penetrance [MP:0011108]| embryonic lethality during organogenesis [MP:0012431]
Affected Gene: Pten
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Source: Mutant Mouse Resource and Research Center (RRID:SCR_002953)
Description: National public repository system for mutant mice. Archives and distributes scientifically valuable spontaneous and induced mutant mouse strains and ES cell lines for use by biomedical research community. Includes breeding/distribution facilities and information coordinating center. Mice strains are cryopreserved, unless live colony must be established. Live mice are supplied from production colony, from colony recovered from cryopreservation, or via micro-injection of cell line into host blastocysts. MMRRC member facilities also develop technologies to improve handling of mutant mice, including advances in assisted reproductive techniques, cryobiology, genetic analysis, phenotyping and infectious disease diagnostics.
URL: http://www.mmrrc.org/
Source Database: Mutant Mouse Resource and Research Center (MMRRC)
The NIDDK Information Network (dkNET) serves the needs of basic and clinical investigators by providing seamless access to large pools of data and research resources relevant to the mission of The National Institute of Diabetes Digestive and Kidney Diseases (NIDDK). dkNET is hosted at University of California San Diego, and is supported by NIH NIDDK grant U24DK097771.
Email: info_at_ dknet.org
