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URL: https://www.mmrrc.org/catalog/sds.php?mmrrc_id=42050
Proper Citation: RRID:MMRRC_042050-JAX
Description: Mus musculus with name B6.Cg-Apptm1Dbo Tg(APPswe,PSEN1dE9)85Dbo/Mmjax from MMRRC.
Species: Mus musculus
Notes: Research areas: Immunology and Inflammation, Models for Human Disease, Neurobiology; Mutation Type: Transgenic ; Collection:
Phenotype: weakness [MP:0000746]| decreased brain size [MP:0000774]| small cerebellum [MP:0000852]| Purkinje cell degeneration [MP:0000876]| demyelination [MP:0000921]| abnormal neuromuscular synapse morphology [MP:0001053]| decreased body weight [MP:0001262]| weight loss [MP:0001263]| decreased body size [MP:0001265]| ataxia [MP:0001393]| hypoactivity [MP:0001402]| impaired coordination [MP:0001405]| spinning [MP:0001411]| abnormal spatial learning [MP:0001463]| impaired righting response [MP:0001523]| intracerebral hemorrhage [MP:0001916]| reduced fertility [MP:0001921]| premature death [MP:0002083]| gliosis [MP:0002183]| abnormal long term potentiation [MP:0002207]| abnormal active avoidance behavior [MP:0002798]| abnormal neuron morphology [MP:0002882]| abnormal locomotor activation [MP:0003313]| astrocytosis [MP:0003354]| pallor [MP:0003717]| head tilt [MP:0005191]| hematoma [MP:0008817]| absent gastric milk in neonates [MP:0009546]| abnormal neuron differentiation [MP:0009937]| decreased grip strength [MP:0010053]| increased brain cholesterol level [MP:0010162]| postnatal lethality [MP:0011085]| complete penetrance [MP:0011086]| postnatal lethality [MP:0011110]| incomplete penetrance [MP:0020408]
Affected Gene: App|APP||PSEN1||App
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No rating or validation information has been found for B6.Cg-Apptm1Dbo Tg(APPswe,PSEN1dE9)85Dbo/Mmjax.
No alerts have been found for B6.Cg-Apptm1Dbo Tg(APPswe,PSEN1dE9)85Dbo/Mmjax.
Source: Integrated Animals
Source Database: Mutant Mouse Resource and Research Center (MMRRC)
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