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URL: https://www.mmrrc.org/catalog/sds.php?mmrrc_id=41407
Proper Citation: RRID:MMRRC_041407-UCD
Description: Mus musculus with name B6J.Cg-Ikbkgtm2Dln Tnfrsf1atm1Mak/Mmucd from MMRRC.
Species: Mus musculus
Notes: Research areas: Apoptosis, Cell Biology, Dermatology, Developmental Biology, Hematology, Immunology and Inflammation, Models for Human Disease, Neurobiology, Research Tools; Mutation Type: Targeted Mutation ; Collection:
Phenotype: increased bone mineral density [MP:0000062]| increased neutrophil cell number [MP:0000219]| abnormal vascular development [MP:0000259]| spleen hyperplasia [MP:0000693]| open neural tube [MP:0000929]| thick epidermis [MP:0001219]| epidermal hyperplasia [MP:0001222]| decreased body weight [MP:0001262]| abnormal eye development [MP:0001286]| increased incidence of corneal inflammation [MP:0001313]| anemia [MP:0001577]| decreased IgG level [MP:0001805]| liver inflammation [MP:0001860]| blindness [MP:0002001]| postnatal lethality [MP:0002082]| premature death [MP:0002083]| abnormal spleen germinal center morphology [MP:0002359]| decreased susceptibility to bacterial infection [MP:0002411]| granulomatous inflammation [MP:0002500]| glomerulonephritis [MP:0002743]| impaired skin barrier function [MP:0002796]| decreased hemoglobin content [MP:0002874]| curly tail [MP:0003051]| liver fibrosis [MP:0003333]| abnormal response/metabolism to endogenous compounds [MP:0003638]| broad limb buds [MP:0004574]| decreased susceptibility to experimental autoimmune encephalomyelitis [MP:0004800]| increased susceptibility to systemic lupus erythematosus [MP:0004801]| increased susceptibility to autoimmune diabetes [MP:0004803]| decreased susceptibility to autoimmune diabetes [MP:0004804]| dilated vasculature [MP:0004938]| skin inflammation [MP:0004947]| corneal vascularization [MP:0005542]| decreased cornea thickness [MP:0005543]| increased circulating glucose level [MP:0005559]| abnormal corneal epithelium morphology [MP:0006000]| increased susceptibility to induced colitis [MP:0008537]| decreased susceptibility to induced colitis [MP:0008539]| increased circulating tumor necrosis factor level [MP:0008553]| decreased circulating interleukin-6 level [MP:0008597]| increased sensitivity to induced cell death [MP:0008943]| decreased sensitivity to induced morbidity/mortality [MP:0009764]| increased susceptibility to bacterial infection induced morbidity/mortality [MP:0009788]| postnatal lethality [MP:0011086]| incomplete penetrance [MP:0011098]| embryonic lethality during organogenesis [MP:0011099]| complete penetrance [MP:0011101]| lethality throughout fetal growth and development [MP:0020154]
Affected Gene: |Tnfrsf1a|Ikbkg|
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Source: Mutant Mouse Resource and Research Center (RRID:SCR_002953)
Description: National public repository system for mutant mice. Archives and distributes scientifically valuable spontaneous and induced mutant mouse strains and ES cell lines for use by biomedical research community. Includes breeding/distribution facilities and information coordinating center. Mice strains are cryopreserved, unless live colony must be established. Live mice are supplied from production colony, from colony recovered from cryopreservation, or via micro-injection of cell line into host blastocysts. MMRRC member facilities also develop technologies to improve handling of mutant mice, including advances in assisted reproductive techniques, cryobiology, genetic analysis, phenotyping and infectious disease diagnostics.
URL: http://www.mmrrc.org/
Source Database: Mutant Mouse Resource and Research Center (MMRRC)
The NIDDK Information Network (dkNET) serves the needs of basic and clinical investigators by providing seamless access to large pools of data and research resources relevant to the mission of The National Institute of Diabetes Digestive and Kidney Diseases (NIDDK). dkNET is hosted at University of California San Diego, and is supported by NIH NIDDK grant U24DK097771.
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