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URL: https://www.mmrrc.org/catalog/sds.php?mmrrc_id=37398
Proper Citation: RRID:MMRRC_037398-UNC
Description: Mus musculus with name C57BL/6NTac-Il15tm1Imx/TacMmnc from MMRRC.
Species: Mus musculus
Notes: Research areas: ; Mutation Type: Targeted Mutation ; Collection:
Phenotype: increased monocyte cell number [MP:0000220]| abnormal immune system morphology [MP:0000685]| decreased body weight [MP:0001262]| abnormal immune system physiology [MP:0001790]| altered susceptibility to infection [MP:0001793]| decreased IgG level [MP:0001805]| decreased IgM level [MP:0001806]| premature death [MP:0002083]| small lymph nodes [MP:0002217]| abnormal dendritic cell physiology [MP:0002376]| decreased immunoglobulin level [MP:0002460]| abnormal lymphocyte morphology [MP:0002619]| abnormal cytokine secretion [MP:0003009]| abnormal decidualization [MP:0003845]| abnormal uterine artery morphology [MP:0003995]| abnormal CD8-positive [MP:0004392]| alpha-beta T cell physiology [MP:0004794]| increased anti-nuclear antigen antibody level [MP:0004801]| increased susceptibility to systemic lupus erythematosus [MP:0004974]| decreased regulatory T cell number [MP:0005027]| increased susceptibility to parasitic infection [MP:0005070]| impaired natural killer cell mediated cytotoxicity [MP:0005616]| decreased susceptibility to type IV hypersensitivity reaction [MP:0008045]| decreased NK cell number [MP:0008047]| absent uterine NK cells [MP:0008050]| decreased memory T cell number [MP:0008053]| abnormal NK cell differentiation [MP:0008079]| decreased CD8-positive [MP:0008080]| alpha-beta T cell number [MP:0008127]| abnormal CD8-positive [MP:0008363]| alpha-beta T cell differentiation [MP:0008470]| decreased dendritic cell number [MP:0008499]| decreased CD8-positive [MP:0008500]| gamma-delta intraepithelial T cell number [MP:0008501]| abnormal spleen B cell follicle morphology [MP:0008567]| increased IgG1 level [MP:0008664]| increased IgG2a level [MP:0008827]| increased IgG2b level [MP:0009338]| decreased interferon-gamma secretion [MP:0009789]| decreased interleukin-12 secretion [MP:0009791]| abnormal thymus cell ratio [MP:0020519]
Affected Gene: Il15
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Source: Mutant Mouse Resource and Research Center (RRID:SCR_002953)
Description: National public repository system for mutant mice. Archives and distributes scientifically valuable spontaneous and induced mutant mouse strains and ES cell lines for use by biomedical research community. Includes breeding/distribution facilities and information coordinating center. Mice strains are cryopreserved, unless live colony must be established. Live mice are supplied from production colony, from colony recovered from cryopreservation, or via micro-injection of cell line into host blastocysts. MMRRC member facilities also develop technologies to improve handling of mutant mice, including advances in assisted reproductive techniques, cryobiology, genetic analysis, phenotyping and infectious disease diagnostics.
URL: http://www.mmrrc.org/
Source Database: Mutant Mouse Resource and Research Center (MMRRC)
The NIDDK Information Network (dkNET) serves the needs of basic and clinical investigators by providing seamless access to large pools of data and research resources relevant to the mission of The National Institute of Diabetes Digestive and Kidney Diseases (NIDDK). dkNET is hosted at University of California San Diego, and is supported by NIH NIDDK grant U24DK097771.
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