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URL: https://www.mmrrc.org/catalog/sds.php?mmrrc_id=37337
Proper Citation: RRID:MMRRC_037337-MU
Description: Mus musculus with name 129S7-Gnai2tm1Lbi/Mmmh from MMRRC.
Species: Mus musculus
Notes: Research areas: Cancer, Cardiovascular, Cell Biology, Dermatology, Developmental Biology, Diabetes, Endocrine Deficiency, Hematology, Immunology and Inflammation, Metabolism, Models for Human Disease, Neurobiology, Obesity, Reproduction, Research Tools, Sensorineural; Mutation Type: Targeted Mutation ; Collection:
Phenotype: rib fusion [MP:0000154]| abnormal leukocyte cell number [MP:0000217]| increased neutrophil cell number [MP:0000219]| increased monocyte cell number [MP:0000220]| increased granulocyte number [MP:0000322]| abnormal large intestine morphology [MP:0000489]| rectal prolapse [MP:0000493]| abnormal colon morphology [MP:0000495]| intestinal ulcer [MP:0000512]| abnormal liver morphology [MP:0000598]| abnormal immune system morphology [MP:0000685]| increased thymocyte number [MP:0000714]| weakness [MP:0000746]| decreased body weight [MP:0001262]| weight loss [MP:0001263]| cyanosis [MP:0001575]| abnormal digestive system physiology [MP:0001663]| chronic diarrhea [MP:0001665]| postnatal growth retardation [MP:0001732]| abnormal immune system physiology [MP:0001790]| increased inflammatory response [MP:0001846]| respiratory distress [MP:0001954]| premature death [MP:0002083]| abnormal T cell physiology [MP:0002444]| increased immunoglobulin level [MP:0002461]| abnormal neutrophil physiology [MP:0002463]| abnormal eosinophil physiology [MP:0002465]| increased IgG level [MP:0002493]| increased IgM level [MP:0002494]| increased IgA level [MP:0002495]| megacolon [MP:0002731]| colitis [MP:0002816]| increased heart weight [MP:0002833]| fatigue [MP:0002899]| increased intestinal adenocarcinoma incidence [MP:0002957]| abnormal cytokine secretion [MP:0003009]| peritoneal inflammation [MP:0003303]| large intestinal inflammation [MP:0003304]| abnormal leukocyte adhesion [MP:0003628]| abnormal response/metabolism to endogenous compounds [MP:0003638]| pulmonary edema [MP:0003828]| abnormal large intestine crypts of Lieberkuhn morphology [MP:0004842]| dilated heart [MP:0004937]| increased eosinophil cell number [MP:0005011]| decreased eosinophil cell number [MP:0005012]| increased lymphocyte cell number [MP:0005013]| increased T cell number [MP:0005015]| increased susceptibility to parasitic infection [MP:0005027]| ascites [MP:0005324]| increased T cell proliferation [MP:0005348]| increased single-positive T cell number [MP:0008082]| abnormal sternocostal joint morphology [MP:0008148]| increased tumor necrosis factor secretion [MP:0008560]| increased interferon-gamma secretion [MP:0008566]| increased circulating interferon-gamma level [MP:0008577]| increased circulating interleukin-4 level [MP:0008602]| increased circulating interleukin-5 level [MP:0008626]| increased interleukin-1 beta secretion [MP:0008657]| increased interleukin-2 secretion [MP:0008687]| abnormal cytokine level [MP:0008713]| increased physiological sensitivity to xenobiotic [MP:0008873]| decreased physiological sensitivity to xenobiotic [MP:0008874]| decreased birth body size [MP:0009703]| abnormal cellular extravasation [MP:0009858]| postnatal lethality [MP:0011085]| complete penetrance [MP:0011086]| postnatal lethality [MP:0011102]| incomplete penetrance [MP:0011111]
Affected Gene: Gnai2
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Source: Mutant Mouse Resource and Research Center (RRID:SCR_002953)
Description: National public repository system for mutant mice. Archives and distributes scientifically valuable spontaneous and induced mutant mouse strains and ES cell lines for use by biomedical research community. Includes breeding/distribution facilities and information coordinating center. Mice strains are cryopreserved, unless live colony must be established. Live mice are supplied from production colony, from colony recovered from cryopreservation, or via micro-injection of cell line into host blastocysts. MMRRC member facilities also develop technologies to improve handling of mutant mice, including advances in assisted reproductive techniques, cryobiology, genetic analysis, phenotyping and infectious disease diagnostics.
URL: http://www.mmrrc.org/
Source Database: Mutant Mouse Resource and Research Center (MMRRC)