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URL: https://www.mmrrc.org/catalog/sds.php?mmrrc_id=36310
Proper Citation: RRID:MMRRC_036310-UCD
Description: Mus musculus with name B6.129S4-Atp8b1tm1Nbf/Mmucd from MMRRC.
Species: Mus musculus
Notes: Research areas: Cell Biology, Internal/Organ, Metabolism, Models for Human Disease, Sensorineural; Mutation Type: Targeted Mutation ; Collection:
Phenotype: abnormal cochlea morphology [MP:0000031]| organ of Corti degeneration [MP:0000043]| enlarged liver [MP:0000599]| abnormal liver physiology [MP:0000609]| cholestasis [MP:0000610]| weight loss [MP:0001263]| postnatal growth retardation [MP:0001732]| abnormal cochlear ganglion morphology [MP:0002855]| increased circulating alanine transaminase level [MP:0002941]| increased circulating alkaline phosphatase level [MP:0002968]| increased liver weight [MP:0002981]| bile duct proliferation [MP:0003255]| cochlear inner hair cell degeneration [MP:0004398]| cochlear outer hair cell degeneration [MP:0004404]| degeneration of organ of Corti supporting cells [MP:0004465]| abnormal outer hair cell stereociliary bundle morphology [MP:0004527]| abnormal bile secretion [MP:0004772]| abnormal bile salt level [MP:0004774]| increased bile salt level [MP:0004789]| increased circulating aspartate transaminase level [MP:0005343]| increased circulating bilirubin level [MP:0005344]| abnormal bile salt homeostasis [MP:0005365]| increased sensitivity to induced morbidity/mortality [MP:0009763]| increased susceptibility to weight loss [MP:0010180]| increased or absent threshold for auditory brainstem response [MP:0011967]
Affected Gene: Atp8b1
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Issue
Warning. Researchers have noted that this genotype does not sufficiently model human intrahepatic cholestasis.
Source: Mutant Mouse Resource and Research Center (RRID:SCR_002953)
Description: National public repository system for mutant mice. Archives and distributes scientifically valuable spontaneous and induced mutant mouse strains and ES cell lines for use by biomedical research community. Includes breeding/distribution facilities and information coordinating center. Mice strains are cryopreserved, unless live colony must be established. Live mice are supplied from production colony, from colony recovered from cryopreservation, or via micro-injection of cell line into host blastocysts. MMRRC member facilities also develop technologies to improve handling of mutant mice, including advances in assisted reproductive techniques, cryobiology, genetic analysis, phenotyping and infectious disease diagnostics.
URL: http://www.mmrrc.org/
Source Database: Mutant Mouse Resource and Research Center (MMRRC)
The NIDDK Information Network (dkNET) serves the needs of basic and clinical investigators by providing seamless access to large pools of data and research resources relevant to the mission of The National Institute of Diabetes Digestive and Kidney Diseases (NIDDK). dkNET is hosted at University of California San Diego, and is supported by NIH NIDDK grant U24DK097771.
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