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URL: https://www.mmrrc.org/catalog/sds.php?mmrrc_id=34849
Proper Citation: RRID:MMRRC_034849-JAX
Description: Mus musculus with name B6.Cg-Nos2tm1Lau Tg(Thy1-APPSwDutIowa)BWevn/Mmjax from MMRRC.
Species: Mus musculus
Notes: Research areas: ; Mutation Type: Transgenic ; Collection:
Phenotype: abnormal systemic arterial blood pressure [MP:0000230]| abnormal angiogenesis [MP:0000260]| abnormal heart morphology [MP:0000266]| abnormal immune system morphology [MP:0000685]| abnormal corpus callosum morphology [MP:0000780]| hippocampal neuron degeneration [MP:0000811]| abnormal testis morphology [MP:0001146]| abnormal eating behavior [MP:0001431]| abnormal sleep pattern [MP:0001501]| decreased white adipose tissue amount [MP:0001783]| abnormal inflammatory response [MP:0001845]| decreased inflammatory response [MP:0001876]| abnormal gametogenesis [MP:0001929]| increased tumor incidence [MP:0002020]| decreased tumor incidence [MP:0002052]| abnormal glucose homeostasis [MP:0002078]| abnormal respiratory system physiology [MP:0002133]| abnormal reproductive system morphology [MP:0002160]| altered tumor susceptibility [MP:0002166]| neurodegeneration [MP:0002229]| increased susceptibility to bacterial infection [MP:0002412]| abnormal adaptive immunity [MP:0002420]| abnormal blood coagulation [MP:0002551]| enhanced wound healing [MP:0002724]| increased growth rate [MP:0002865]| increased insulin sensitivity [MP:0002891]| abnormal bone mineralization [MP:0002896]| increased susceptibility to pharmacologically induced seizures [MP:0002906]| decreased circulating alanine transaminase level [MP:0002942]| increased myocardial infarction size [MP:0003037]| abnormal frequency of paradoxical sleep [MP:0003194]| increased neuron apoptosis [MP:0003203]| neuron degeneration [MP:0003224]| loss of hippocampal neurons [MP:0003240]| amyloid beta deposits [MP:0003329]| decreased susceptibility to induced choroidal neovascularization [MP:0003434]| decreased tumor growth/size [MP:0003447]| abnormal tumor morphology [MP:0003448]| abnormal physiological neovascularization [MP:0003710]| increased tumor growth/size [MP:0003721]| abnormal bone structure [MP:0003795]| increased left ventricle developed pressure [MP:0003823]| increased mortality induced by ionizing radiation [MP:0003992]| abnormal brain interneuron morphology [MP:0004101]| tau protein deposits [MP:0004250]| abnormal respiratory bronchiole morphology [MP:0004389]| abnormal surfactant physiology [MP:0004782]| increased testis weight [MP:0004851]| skin inflammation [MP:0004947]| abnormal osteoclast morphology [MP:0004982]| abnormal brain wave pattern [MP:0004994]| decreased susceptibility to injury [MP:0005166]| abnormal male meiosis [MP:0005169]| improved glucose tolerance [MP:0005292]| abnormal heart ventricle morphology [MP:0005294]| abnormal enzyme/coenzyme level [MP:0005319]| abnormal myocardium layer morphology [MP:0005329]| increased T cell proliferation [MP:0005348]| abnormal fertilization [MP:0005410]| abnormal platelet physiology [MP:0005464]| increased circulating creatinine level [MP:0005553]| increased circulating antidiuretic hormone level [MP:0005610]| decreased circulating aspartate transaminase level [MP:0005632]| decreased circulating leptin level [MP:0005668]| decreased systemic arterial systolic blood pressure [MP:0006264]| enlarged seminiferous tubules [MP:0006308]| increased single-positive T cell number [MP:0008082]| abnormal hippocampus CA3 region morphology [MP:0008267]| abnormal subiculum morphology [MP:0008287]| abnormal spatial reference memory [MP:0008414]| abnormal long term spatial reference memory [MP:0008432]| decreased susceptibility to induced colitis [MP:0008539]| decreased neuron number [MP:0008948]| increased urine pH [MP:0009349]| enlarged inguinal lymph nodes [MP:0009623]| abnormal blood homeostasis [MP:0009642]| increased sensitivity to induced morbidity/mortality [MP:0009763]| decreased oligodendrocyte number [MP:0009808]| increased tumor latency [MP:0009828]| decreased tumor latency [MP:0010308]| prenatal lethality [MP:0011101]| incomplete penetrance [MP:0011939]| increased food intake [MP:0020478]| abnormal circadian sleep/wake cycle [MP:0020537]| decreased subiculum size [MP:0030013]| improved central nervous system regeneration [MP:0030603]
Affected Gene: |Thy1||Nos2
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Source: Mutant Mouse Resource and Research Center (RRID:SCR_002953)
Description: National public repository system for mutant mice. Archives and distributes scientifically valuable spontaneous and induced mutant mouse strains and ES cell lines for use by biomedical research community. Includes breeding/distribution facilities and information coordinating center. Mice strains are cryopreserved, unless live colony must be established. Live mice are supplied from production colony, from colony recovered from cryopreservation, or via micro-injection of cell line into host blastocysts. MMRRC member facilities also develop technologies to improve handling of mutant mice, including advances in assisted reproductive techniques, cryobiology, genetic analysis, phenotyping and infectious disease diagnostics.
URL: http://www.mmrrc.org/
Source Database: Mutant Mouse Resource and Research Center (MMRRC)
The NIDDK Information Network (dkNET) serves the needs of basic and clinical investigators by providing seamless access to large pools of data and research resources relevant to the mission of The National Institute of Diabetes Digestive and Kidney Diseases (NIDDK). dkNET is hosted at University of California San Diego, and is supported by NIH NIDDK grant U24DK097771.
Email: info_at_ dknet.org
