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URL: https://www.mmrrc.org/catalog/sds.php?mmrrc_id=30019
Proper Citation: RRID:MMRRC_030019-UCD
Description: Mus musculus with name C57BL/6J-Gimap5m1Btlr/Mmucd from MMRRC.
Species: Mus musculus
Notes: Research areas: Apoptosis, Cancer, Developmental Biology, Diabetes, Hematology, Immunology and Inflammation, Models for Human Disease; Mutation Type: chemically induced mutation ; Collection: Beutler Mutagenetix
Phenotype: increased neutrophil cell number [MP:0000219]| extramedullary hematopoiesis [MP:0000240]| increased granulocyte number [MP:0000322]| abnormal intestinal epithelium morphology [MP:0000488]| abnormal liver morphology [MP:0000598]| decreased thymocyte number [MP:0000715]| anemia [MP:0001577]| postnatal growth retardation [MP:0001732]| decreased IgG level [MP:0001805]| decreased IgM level [MP:0001806]| intestinal inflammation [MP:0001858]| premature death [MP:0002083]| abnormal bone marrow cell morphology/development [MP:0002398]| abnormal B cell physiology [MP:0002459]| colitis [MP:0002816]| decreased hemoglobin content [MP:0002874]| thrombocytopenia [MP:0003179]| thymus atrophy [MP:0003644]| increased hematopoietic stem cell number [MP:0004809]| abnormal large intestine crypts of Lieberkuhn morphology [MP:0004842]| decreased B-1 B cell number [MP:0004978]| decreased lymphocyte cell number [MP:0005016]| decreased B cell number [MP:0005017]| diarrhea [MP:0005036]| decreased B cell proliferation [MP:0005093]| cachexia [MP:0005150]| abnormal B cell proliferation [MP:0005153]| abnormal response to transplant [MP:0005671]| abnormal common myeloid progenitor cell morphology [MP:0006410]| decreased NK T cell number [MP:0008040]| abnormal NK T cell physiology [MP:0008042]| decreased NK cell number [MP:0008045]| decreased CD8-positive [MP:0008079]| alpha-beta T cell number [MP:0008211]| decreased mature B cell number [MP:0008249]| abnormal common lymphocyte progenitor cell morphology [MP:0008470]| abnormal spleen B cell follicle morphology [MP:0008495]| decreased IgG1 level [MP:0008496]| decreased IgG2a level [MP:0008497]| decreased IgG2b level [MP:0008498]| decreased IgG3 level [MP:0008561]| decreased tumor necrosis factor secretion [MP:0008567]| decreased interferon-gamma secretion [MP:0008578]| decreased circulating interferon-gamma level [MP:0008603]| decreased circulating interleukin-4 level [MP:0008700]| decreased interleukin-4 secretion [MP:0010067]| increased red blood cell distribution width [MP:0013795]
Affected Gene: Gimap5
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Source: Integrated Animals
Source Database: Mutant Mouse Resource and Research Center (MMRRC)
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