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URL: https://www.mmrrc.org/catalog/sds.php?mmrrc_id=11119
Proper Citation: RRID:MMRRC_011119-UCD
Description: Mus musculus with name C57BL/6-Rc3h1san/Mmucd from MMRRC.
Species: Mus musculus
Notes: Research areas: Cell Biology, Developmental Biology, Diabetes, Hematology, Immunology and Inflammation, Models for Human Disease; Mutation Type: chemically induced mutation ; Collection: NHMRC Australian PhenomeBank
Phenotype: crypts of Lieberkuhn abscesses [MP:0000491]| intestinal ulcer [MP:0000512]| lymphoid hyperplasia [MP:0000688]| enlarged spleen [MP:0000691]| enlarged lymph nodes [MP:0000702]| decreased body weight [MP:0001262]| anemia [MP:0001577]| hepatic necrosis [MP:0001654]| increased activated T cell number [MP:0001829]| increased inflammatory response [MP:0001846]| kidney inflammation [MP:0001859]| liver inflammation [MP:0001860]| increased T cell derived lymphoma incidence [MP:0002024]| premature death [MP:0002083]| abnormal T cell differentiation [MP:0002145]| abnormal lymph node morphology [MP:0002339]| increased susceptibility to bacterial infection [MP:0002412]| abnormal effector T cell morphology [MP:0002435]| increased IgG level [MP:0002493]| granulomatous inflammation [MP:0002500]| glomerulonephritis [MP:0002743]| colitis [MP:0002816]| thrombocytopenia [MP:0003179]| small intestinal inflammation [MP:0003306]| increased anti-double stranded DNA antibody level [MP:0004762]| increased anti-nuclear antigen antibody level [MP:0004794]| abnormal small intestine crypts of Lieberkuhn morphology [MP:0004841]| increased spleen weight [MP:0004952]| increased T cell proliferation [MP:0005348]| increased CD4-positive [MP:0008074]| alpha beta T cell number [MP:0008108]| abnormal small intestinal villus morphology [MP:0008522]| abnormal lymph node germinal center morphology [MP:0008553]| increased circulating tumor necrosis factor level [MP:0008895]| abnormal intraepithelial T cell number [MP:0009481]| cecum inflammation [MP:0009482]| ileum inflammation [MP:0010186]| increased T follicular helper cell number [MP:0010189]| abnormal T follicular helper cell physiology [MP:0010268]
Affected Gene: Rc3h1
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Source: Integrated Animals
Source Database: Mutant Mouse Resource and Research Center (MMRRC)
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