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Proper Citation: RRID:MGI:6263474
Description: Allele Detail: Targeted This is a legacy resource.
Species: Mus musculus
Notes: Allele Detail: Targeted This is a legacy resource.
Phenotype: decreased body length, increased plasmacytoid dendritic cell number, abnormal humerus morphology, increased red blood cell distribution width, increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number, increased memory-marker gamma-delta T cell number, increased circulating bilirubin level, increased CD8-positive, naive alpha-beta T cell number, increased circulating sodium level, decreased Ly6C low monocyte number, increased Ly6C-positive NK T cell number, abnormal vertebrae morphology, increased mean corpuscular hemoglobin, abnormal rib morphology, decreased CD5-positive gamma-delta T cell number, increased KLRG1-positive T-helper cell number, abnormal cranium morphology, decreased circulating potassium level, decreased CD4-positive, alpha beta T cell number, decreased NK T cell number, abnormal coat/hair pigmentation, abnormal thoracic cage shape, abnormal cornea morphology, decreased alpha-beta T cell number, decreased caudal vertebrae number, increased Ly6C high monocyte number, increased CD8-positive, alpha-beta T cell number, increased NK cell number, decreased circulating glucose level, increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number, decreased CD4-positive NK T cell number, decreased germinal center B cell number, abnormal zygomatic bone morphology, decreased NK cell number, decreased gamma-delta T cell number, decreased circulating fructosamine level, decreased circulating insulin level, thrombocytopenia, decreased circulating free fatty acid level, increased follicular B cell number, decreased memory-marker CD4-negative NK T cell number, decreased Ly6C-positive mature NK cell number, abnormal joint morphology, kyphosis, improved glucose tolerance, decreased T-helper cell number, increased effector memory T-helper cell number, increased memory-marker NK cell number, increased granulocyte number, increased circulating alkaline phosphatase level, abnormal tail morphology, abnormal tibia morphology, abnormal femur morphology, increased bone mineral content, decreased memory-marker CD4-positive NK T cell number, abnormal radius morphology, abnormal fibula morphology, abnormal ulna morphology, increased CD4-negative NK T cell number, decreased T cell number, abnormal pelvic girdle bone morphology, decreased KLRG1-positive NK cell number, abnormal spine curvature, decreased lean body mass, increased neutrophil cell number, decreased early germinal center B cell number, increased eosinophil cell number, decreased effector memory T-helper cell number, decreased blood urea nitrogen level, increased KLRG1+ CD8 alpha beta T cell number, decreased erythrocyte cell number, increased lean body mass, decreased total body fat amount, abnormal bone structure, decreased circulating calcium level, female infertility, decreased KLRG1-positive T-helper cell number, increased KLRG1-positive CD4-negative NK T cell number, decreased circulating triglyceride level
Affected Gene: Sik3
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No rating or validation information has been found for Sik3tm1a(EUCOMM)Hmgu/Sik3tm1a(EUCOMM)Hmgu.
No alerts have been found for Sik3tm1a(EUCOMM)Hmgu/Sik3tm1a(EUCOMM)Hmgu.
Source: MGI
Source Database: MGI, Mouse Genome Informatics MGI
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