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Proper Citation: RRID:MGI:4459433
Description: Allele Detail: Gene trapped This is a legacy resource.
Species: Mus musculus
Notes: Allele Detail: Gene trapped This is a legacy resource.
Phenotype: decreased immature B cell number, spontaneous chromosome breakage, decreased IgG1 level, decreased splenocyte number, decreased thymocyte number, abnormal seminiferous tubule epithelium morphology, abnormal class switch recombination, increased cellular sensitivity to gamma-irradiation, seminiferous tubule degeneration, increased mortality induced by gamma-irradiation, increased thymocyte apoptosis, increased sarcoma incidence, reduced male fertility, premature death, postnatal growth retardation, oligozoospermia, increased mammary adenocarcinoma incidence, increased lymphoma incidence, decreased IgG3 level, small testis, increased skin tumor incidence, decreased IgG2b level, decreased body size, decreased T cell number, induced chromosome breakage, decreased CD8-positive, alpha-beta T cell number, decreased CD4-positive, alpha beta T cell number, increased T cell derived lymphoma incidence, decreased B cell number, azoospermia, abnormal spermatogonia morphology, decreased bone marrow cell number, decreased fibroblast proliferation, decreased body weight, abnormal spermatogenesis, abnormal spermatocyte morphology, decreased double-negative T cell number, decreased double-positive T cell number, decreased litter size, decreased pre-B cell number, decreased pro-B cell number
Affected Gene: Rnf8
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No rating or validation information has been found for Rnf8Gt(AS0574)Wtsi/Rnf8Gt(AS0574)Wtsi.
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Source: Integrated Animals
Source Database: MGI, Mouse Genome Informatics MGI
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