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Proper Citation: RRID:MGI:3819129
Description: Allele Detail: Chemically induced (ENU) This is a legacy resource.
Species: Mus musculus
Notes: Allele Detail: Chemically induced (ENU) This is a legacy resource.
Phenotype: hypochromic microcytic anemia, extramedullary hematopoiesis, decreased mean corpuscular volume, decreased mature gamma-delta T cell number, decreased mature B cell number, decreased lymphocyte cell number, decreased hematocrit, decreased double-positive T cell number, decreased T cell proliferation, decreased CD8-positive, alpha-beta T cell number, decreased CD4-positive, alpha beta T cell number, cardiac fibrosis, amyloidosis, abnormal thymus lobule morphology, abnormal thoracic cavity morphology, abnormal renal glomerulus morphology, abnormal regulatory T cell number, abnormal lymphopoiesis, abnormal liver morphology, abnormal erythroid progenitor cell morphology, abnormal erythrocyte osmotic lysis, abnormal epididymis morphology, acanthocytosis, abnormal common myeloid progenitor cell morphology, abnormal CD4-positive T cell differentiation, dacryocytosis, lung inflammation, lymph node hypoplasia, liver inflammation, increased tumor necrosis factor secretion, increased neutrophil cell number, increased leukocyte cell number, increased interleukin-6 secretion, increased interleukin-17 secretion, poikilocytosis, reticulocytosis, increased double-negative T cell number, schistocytosis, increased circulating interleukin-6 level, increased circulating interleukin-17 level, impaired neutrophil phagocytosis, impaired neutrophil chemotaxis, spleen hyperplasia, thymus hypoplasia, abnormal immune system organ morphology, impaired macrophage phagocytosis, heart inflammation
Affected Gene: Nckap1l
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Source: MGI
Source Database: MGI, Mouse Genome Informatics MGI
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