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Proper Citation: RRID:MGI:3805120
Description: Allele Detail: Targeted This is a legacy resource.
Species: Mus musculus
Notes: Allele Detail: Targeted This is a legacy resource.
Phenotype: parakeratosis, abnormal large intestine crypts of Lieberkuhn morphology, increased enterocyte cell number, lethality throughout fetal growth and development, incomplete penetrance, abnormal lung development, abnormal enterocyte proliferation, abnormal epidermis stratum basale morphology, abnormal enterocyte morphology, abnormal small intestinal villus morphology, abnormal intestinal enteroendocrine cell morphology, abnormal keratinocyte differentiation, retina hyperplasia, lung epithelium hyperplasia, increased liver tumor incidence, premature death, fetal growth retardation, epidermal hyperplasia, disorganized suprabasal layer, decreased survivor rate, abnormal epidermis stratum granulosum morphology, abnormal intestinal goblet cell morphology, impaired skin barrier function, abnormal small intestinal microvillus morphology, abnormal placental labyrinth vasculature morphology, underdeveloped hair follicles
Affected Gene: Sav1
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Source: Integrated Animals
Source Database: MGI, Mouse Genome Informatics MGI
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