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URL: https://doi.org/10.5281/zenodo.15249620
Proper Citation: SPINA Carb (RRID:SCR_026848)
Description: Software tool to deliver estimated structure parameters of endocrine feedback control systems in vivo from serum or plasma hormone levels. Used for the evaluation of insulin-glucose homeostasis. Allows for calculating the secretory capacity of pancreatic beta cells (SPINA-GBeta), insulin receptor gain (SPINA-GR) and a static disposition index (SPINA-DI) from fasting concentrations of insulin and glucose. Additionally, HOMA, QUICKI and other calculated parameters are delivered as well. Binaries are available for macOS and Windows. For other operating systems, including Linux, Solaris and BSD, SPINA Carb is available as source code. Building from source requires Lazarus/Free Pascal. A special version of the calculation engine is available for modern S implementations, e.g. R.
Abbreviations: SPINA, SPINA Carb
Synonyms: Structure Parameter Inference Approach, Structure Parameter Inference Approach Carbohydrate Homeostasis
Resource Type: software resource, software application, standalone software, data analytics software
Defining Citation: PMID:36271244
Keywords: SPINA, SPINA Carb, secretory capacity evaluation, clinical calculator, Insulin, Glucose, Insulin-glucose homeostasis, prediabetes syndrome, insulin resistance
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The NIDDK Information Network (dkNET) serves the needs of basic and clinical investigators by providing seamless access to large pools of data and research resources relevant to the mission of The National Institute of Diabetes Digestive and Kidney Diseases (NIDDK). dkNET is hosted at University of California San Diego, and is supported by NIH NIDDK grant 2U24DK097771-09.
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