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URL: http://bioinf.uab.es/aggrescan/
Proper Citation: Aggrescan: The Hot Spot Finder (RRID:SCR_008403)
Description: Web-based tool for identifying hot spots of aggregation in polypeptides. Aggrescan uses an aggregation-propensity scale for natural amino acids derived from in vivo experiments and on the assumption that short and specific sequence stretches modulate protein aggregation. The algorithm is shown to identify a series of protein fragments involved in the aggregation of disease-related proteins and to predict the effect of genetic mutations on their deposition propensities. It also provides new insights into the differential aggregation properties displayed by globular proteins, natively unfolded polypeptides, amyloidogenic proteins and proteins found in bacterial inclusion bodies.
Abbreviations: Aggrescan
Resource Type: data analysis service, analysis service resource, service resource, production service resource
Defining Citation: PMID:17324296
Keywords: aggregation, amino acid, protein, mutation, polypeptide, amyloid, bacterial protein, protein aggregation, neurodegeneration
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The NIDDK Information Network (dkNET) serves the needs of basic and clinical investigators by providing seamless access to large pools of data and research resources relevant to the mission of The National Institute of Diabetes Digestive and Kidney Diseases (NIDDK). dkNET is hosted at University of California San Diego, and is supported by NIH NIDDK grant 2U24DK097771-09.
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