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URL: http://corg.molgen.mpg.de
Proper Citation: CORG - A database for COmparative Regulatory Genomics (RRID:SCR_007610)
Description: THIS RESOURCE IS NO LONGER IN SERVICE, documented on July 15, 2013. Non-coding DNA segments that are conserved across multiple homologous genomic sequences are good indicators of putative regulatory elements. We use a systematic approach to delineate such conserved non-coding blocks from a collection of vertebrate species. Upstream regions of homologous gene pairs from man, rhesus monkey, mouse, rat, dog, cow, chicken, tetraodon, zebrafish and xenopus are considered for this purpose. Pairwise as well as Multiple alignments based on the pairwise ones are available. Sequence conservation in non-coding, upstream regions of orthologous genes from man and mouse is likely to reflect common regulatory DNA sites. Motivated by this assumption we have delineated a catalogue of conserved non-coding sequence blocks and provide the CORG-''COmparative Regulatory Genomics''-database. The data were computed based on statistically significant local suboptimal alignments of 15 kb regions upstream of the translation start sites of, currently, 10 793 pairs of orthologous genes. The resulting conserved non-coding blocks were annotated with EST matches for easier detection of non-coding mRNA and with hits to known transcription factor binding sites. CORG data are accessible from the ENSEMBL web site via a DAS service as well as a specially developed web service for query and interactive visualization of the conserved blocks and their annotation.
Abbreviations: CORG
Synonyms: COmparative Regulatory Genomics
Resource Type: database, data or information resource
Defining Citation: PMID:15723697, PMID:12519946, PMID:12385988
Keywords: chicken, conserved dna sequence, conserved non-coding sequence, cow, dog, man, mouse, non-coding sequence, rat, rhesus monkey, tetraodon, xenopus, zebrafish
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Max Planck Institute for Molecular Genetics; Berlin; Germany |
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The NIDDK Information Network (dkNET) serves the needs of basic and clinical investigators by providing seamless access to large pools of data and research resources relevant to the mission of The National Institute of Diabetes Digestive and Kidney Diseases (NIDDK). dkNET is hosted at University of California San Diego, and is supported by NIH NIDDK grant 2U24DK097771-09.
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