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URL: http://athina.biol.uoa.gr/PRED-TMR/
Proper Citation: PRED-TMR (RRID:SCR_006203)
Description: A web server that predicts transmembrane domains in proteins using solely information contained in the sequence itself. The algorithm refines a standard hydrophobicity analysis with a detection of potential termini (edges, starts and ends) of transmembrane regions. This allows both to discard highly hydrophobic regions not delimited by clear start and end configurations and to confirm putative transmembrane segments not distinguishable by their hydrophobic composition. The accuracy obtained on a test set of 101 non homologous transmembranes proteins with reliable topologies compares well with that of other popular existing methods. Only a slight decrease in prediction accuracy was observed when the algorithm was applied to all transmembrane proteins of the SwissProt database (release 35).
Abbreviations: PRED-TMR
Synonyms: PRED-TMR: A novel method for predicting transmembrane segment in proteins based on a statistical analysis of the SwissProt database
Resource Type: analysis service resource, data analysis service, production service resource, service resource
Defining Citation: PMID:10360978
Keywords: predict, transmembrane segment, protein, algorithm, sequence, membrane protein, protein structure, transmembrane region, hydrophobicity analysis
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