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URL: http://www.treat-nmd.eu/about/related-projects/bioimage-nmd/
Proper Citation: BIOIMAGE-NMD (RRID:SCR_003840)
Description: Project whose objective is to deliver combined structural and molecular imaging biomarkers with proven utility for the detection of therapeutic effects in patients with rare neuromuscular diseases (NMD). The project has three specific objectives: # To develop a new generation of muscle diffusion Magnetic Resonance Imaging (MRI). This diffusion imaging technology will be used to augment a state of the art simultaneous MRI / Magnetic Resonance Spectroscopic Imaging (MRSI) protocol for quantitative muscle imaging. # To provide a proof of principle in Duchenne Muscular Dystrophy (DMD) that simultaneous MRI/MRSI can be used as a biomarker to monitor therapeutic efficacy in clinical trials in neuromuscular diseases. # To develop a novel simultaneous Positron Emission Tomography (PET)/MRI technology to advance innovative drug development programs for personalized medicines based on Antisense Oligonucleotide technology
Abbreviations: BIOIMAGE-NMD
Synonyms: Developing imaging technologies for therapeutic interventions in rare diseases (BIOIMAGE-NMD), Developing imaging technologies for therapeutic interventions in rare diseases
Resource Type: portal, organization portal, consortium, data or information resource
Keywords: biomarker, drug, imaging, therapy, pet, mri, muscle, diffusion, diffusion mri, magnetic resonance spectroscopic imaging, muscle imaging, therapeutic efficacy, drug development, antisense, oligonucleotide
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The NIDDK Information Network (dkNET) serves the needs of basic and clinical investigators by providing seamless access to large pools of data and research resources relevant to the mission of The National Institute of Diabetes Digestive and Kidney Diseases (NIDDK). dkNET is hosted at University of California San Diego, and is supported by NIH NIDDK grant 2U24DK097771-09.
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