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URL: http://www.sanger.ac.uk/science/tools/carol
Proper Citation: CAROL (RRID:SCR_001800)
Description: Software application that is a combined functional annotation score of non-synonymous coding variants. A major challenge in interpreting whole-exome data is predicting which of the discovered variants are deleterious or neutral. To address this question in silico, they have developed a score called Combined Annotation scoRing toOL (CAROL), which combines information from two bioinformatics tools: PolyPhen-2 and SIFT, in order to improve the prediction of the effect of non-synonymous coding variants. The combination of annotation tools can help improve automated prediction of whole-genome/exome non-synonymous variant functional consequences. (entry from Genetic Analysis Software) The software should run on any UNIX or GNU/Linux system.
Abbreviations: CAROL
Synonyms: Combined Annotation scoRing toOL
Resource Type: software resource, software application
Defining Citation: PMID:22261837
Keywords: gene, genetic, genomic, r, prediction, non-synonymous coding variant
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