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URL: http://www.addgene.org/242456
Proper Citation: RRID:Addgene_242456
Insert Name: Caspase 3
Organism: Homo sapiens
Bacterial Resistance: Ampicillin
Vector Backbone Description: Backbone Marker:Vector Builder; Backbone Size:4986; Vector Backbone:pAAV[Exp]:WPRE; Vector Types:Mammalian Expression; Bacterial Resistance:Ampicillin
Comments: This AAV construct expresses taCaspase-3 and T2A linked TEVp using the design of Dr. Nirao Shah for caspase mediated cell ablation (Yang et al. 2013 Cell. https://doi.org/10.1016/j.cell.2013.04.017. PubMed 23663785) and an intersectional strategy for Cre-off and Flp-on expression. Note that the Intersect strategy used here does not make use of "introns" as initially designed by the Deisseroth lab (Fenno et al. 2014 Nat Methods. https://doi.org/10.1038/nmeth.2996. PubMed 24908100). Rather it uses loxP sites in the same orientation to facilitate a Cre-mediated deletion for "off" and inverted FRT sites to facilitate a Flp-mediated inversion for "on".
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No rating or validation information has been found for pAAV-Ef1a-Coff/Fon-taCasp3-T2A-TEVp-WPRE3-BGHpA.
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Source: Addgene
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