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URL: http://www.addgene.org/16816
Proper Citation: RRID:Addgene_16816
Insert Name: Fz1-ER
Organism: Rattus norvegicus
Bacterial Resistance: Ampicillin
Defining Citation: PMID:14688793
Vector Backbone Description: Backbone Size:4095; Vector Backbone:pCS2+; Vector Types:Xenopus Expression; Bacterial Resistance:Ampicillin
Comments: This is a fusion protein consisting of a FKBP domain at the amino terminus of rat Frizzled 1. The expression of the protein is under the control of a CMV promoter. Once expressed the fusion protein enters the endoplasmic reticulum, where it remains trapped (and acts as a dominant negative Frizzled by trapping endogenous Frizzleds) unless one adds proprietary Ariad small molecule reagents that bind to and unfold the FKBP domain, allowing proteolysis and then processing and membrane targeting of the Frizzled 1. Note that the Frizzleds interact in a homo and heteromeric manner. Notes for Use: Construct is 8251bp, made 9/16/02 by Ajamete, and also called Fz1-ER/AKA pC4FZ1agg. Reference: A. Kaykas et al., 2004, Nature Cell Biology vol. 6, pp. 52-58.
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Source: Addgene
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