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Generation of functional human thymic cells from induced pluripotent stem cells.

The Journal of allergy and clinical immunology | 2022

The thymus is a glandular organ that is essential for the formation of the adaptive immune system by educating developing T cells. The thymus is most active during childhood and involutes around the time of adolescence, resulting in a severe reduction or absence of naive T-cell output. The ability to generate a patient-derived human thymus would provide an attractive research platform and enable the development of novel cell therapies.

Pubmed ID: 34331993 RIS Download

Antibodies used in this publication

None found

Associated grants

  • Agency: NIAMS NIH HHS, United States
    Id: T32 AR007411
  • Agency: NCI NIH HHS, United States
    Id: R01 CA213102
  • Agency: NIDDK NIH HHS, United States
    Id: P30 DK116073
  • Agency: NIGMS NIH HHS, United States
    Id: T32 GM136444
  • Agency: NIGMS NIH HHS, United States
    Id: T32 GM008730
  • Agency: NIAID NIH HHS, United States
    Id: T32 AI074491
  • Agency: NIDDK NIH HHS, United States
    Id: R01 DK120444
  • Agency: NCI NIH HHS, United States
    Id: R01 CA149456
  • Agency: NIDDK NIH HHS, United States
    Id: T32 DK120520
  • Agency: NIAID NIH HHS, United States
    Id: R21 AI140044

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